Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pip4k2cprovided by MGI
Official Full Name: phosphatidylinositol-5-phosphate 4-kinase, type II, gammaprovided by MGI
Primary source: MGI:MGI:2152214
See related: Ensembl:ENSMUSG00000025417 AllianceGenome:MGI:2152214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pip5k2c
Summary: Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and identical protein binding activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Predicted to be located in autophagosome; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 43.6), genital fat pad adult (RPKM 30.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127032936..127047508, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127197067..127211628, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
Title: Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
Title: Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
PI5P4Kgamma plays a role in the regulation of the immune system via mTORC1 signaling.
Title: Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain
Title: Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.
PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells.
Title: Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Pip4k2c (e-PCR), detects polymorphism
- UniSTS:527491

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Names: PI(5)P 4-kinase type II gamma; PIP4KII-gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma

NP_001346209.1

EC 2.7.1.149

NP_473438.1

EC 2.7.1.149

XP_006513184.1

EC 2.7.1.149

XP_011241590.1

EC 2.7.1.149

XP_011241591.1

EC 2.7.1.149

XP_036011413.1

EC 2.7.1.149

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359280.1 → NP_001346209.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Status: VALIDATED

Source sequence(s)

AB054591, AC144852, BB856667, BP766151

Consensus CDS

CCDS24232.1

UniProtKB/Swiss-Prot

Q3UFU5, Q91XU3, Q99K02

Conserved Domains (1) summary

cd17311
Location:46 → 418

PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins
NM_054097.3 → NP_473438.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

See identical proteins and their annotated locations for NP_473438.1

Status: VALIDATED

Source sequence(s)

AB054591, AC144852, BB856667

Consensus CDS

CCDS24232.1

UniProtKB/Swiss-Prot

Q3UFU5, Q91XU3, Q99K02

Related

ENSMUSP00000013970.8, ENSMUST00000013970.9

Conserved Domains (1) summary

cd17311
Location:46 → 418

PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127032936..127047508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243289.4 → XP_011241591.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3

Conserved Domains (1) summary

cl28923
Location:46 → 291

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
XM_011243288.4 → XP_011241590.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1

Conserved Domains (1) summary

cl28923
Location:117 → 349

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
XM_006513121.5 → XP_006513184.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

See identical proteins and their annotated locations for XP_006513184.1

Conserved Domains (1) summary

cl28923
Location:117 → 476

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
XM_036155520.1 → XP_036011413.1 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

Conserved Domains (1) summary

cl28923
Location:117 → 476

PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family