Csnk1e casein kinase 1, epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csnk1eprovided by MGI
Official Full Name: casein kinase 1, epsilonprovided by MGI
Primary source: MGI:MGI:1351660
See related: Ensembl:ENSMUSG00000022433 AllianceGenome:MGI:1351660
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: tau; CKIe; CK1epsilon; KC1epsilon
Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression: Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 37.71 cM; 15 E1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79302054..79339779, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79417852..79455579, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.
Title: Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.
Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice.
Title: Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice.
Therapeutic Targeting of Casein Kinase 1delta/epsilon in an Alzheimer's Disease Mouse Model.
Title: Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.
CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h).
Title: Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.
Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm.
Title: CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.
the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit.
Title: Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.
Csnk1e deletion increased mu opioid receptor-dependent behaviors.
Title: Casein kinase 1-epsilon deletion increases mu opioid receptor-dependent behaviors and binge eating1.
Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta.
Title: Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.
Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e may contribute to individual differences in von Frey filament response.
Title: Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
Title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csnk1e (e-PCR), detects polymorphism
- UniSTS:164880

NoName (e-PCR)
- UniSTS:237346

AW457082 (e-PCR)
- UniSTS:180787

AI551861 (e-PCR)
- UniSTS:165943

AI426939 (e-PCR)
- UniSTS:160474

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian behavior	IEA Inferred from Electronic Annotation more info
involved_in circadian behavior	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase I isoform epsilon; casein kinase I

Names: CKI-epsilon; KC1 epsilon

NP_001276827.1

EC 2.7.11.1

NP_001276828.1

EC 2.7.11.1

NP_001346791.1

EC 2.7.11.1

NP_001346792.1

EC 2.7.11.1

NP_001398803.1

EC 2.7.11.1

NP_001398804.1

EC 2.7.11.1

NP_001398805.1

EC 2.7.11.1

NP_001398806.1

EC 2.7.11.1

NP_001398807.1

EC 2.7.11.1

NP_001398808.1

EC 2.7.11.1

NP_001398809.1

EC 2.7.11.1

NP_001398810.1

EC 2.7.11.1

NP_038795.3

EC 2.7.11.1

XP_006521106.1

EC 2.7.11.1

XP_011243952.1

EC 2.7.11.1

XP_011243953.1

EC 2.7.11.1

XP_011243954.1

EC 2.7.11.1

XP_011243955.1

EC 2.7.11.1

XP_011243956.1

EC 2.7.11.1

XP_017172146.1

EC 2.7.11.1

XP_017172149.1

EC 2.7.11.1

XP_030104453.1

EC 2.7.11.1

XP_030104457.1

EC 2.7.11.1

XP_036015339.1

EC 2.7.11.1

XP_036015340.1

EC 2.7.11.1

XP_036015341.1

EC 2.7.11.1

XP_036015342.1

EC 2.7.11.1

XP_036015343.1

EC 2.7.11.1

XP_036015344.1

EC 2.7.11.1

XP_036015345.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289898.3 → NP_001276827.1 casein kinase I isoform epsilon isoform a

See identical proteins and their annotated locations for NP_001276827.1

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27640.1

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Related

ENSMUSP00000113341.2, ENSMUST00000117786.9

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001289899.2 → NP_001276828.1 casein kinase I isoform epsilon isoform b

See identical proteins and their annotated locations for NP_001276828.1

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS70646.1

UniProtKB/TrEMBL

Q3TYE1

Related

ENSMUSP00000113096.2, ENSMUST00000122044.8

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001359862.2 → NP_001346791.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27640.1

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001359863.2 → NP_001346792.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27640.1

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001411874.1 → NP_001398803.1 casein kinase I isoform epsilon isoform b

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/TrEMBL

Q3TYE1
NM_001411875.1 → NP_001398804.1 casein kinase I isoform epsilon isoform b

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/TrEMBL

Q3TYE1
NM_001411876.1 → NP_001398805.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3
NM_001411877.1 → NP_001398806.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3
NM_001411878.1 → NP_001398807.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3
NM_001411879.1 → NP_001398808.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3
NM_001411880.1 → NP_001398809.1 casein kinase I isoform epsilon isoform a

Status: VALIDATED

Source sequence(s)

AC165278

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3
NM_001411881.1 → NP_001398810.1 casein kinase I isoform epsilon isoform c

Status: VALIDATED

Source sequence(s)

AC165278
NM_013767.8 → NP_038795.3 casein kinase I isoform epsilon isoform a

See identical proteins and their annotated locations for NP_038795.3

Status: VALIDATED

Source sequence(s)

AC165278

Consensus CDS

CCDS27640.1

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Related

ENSMUSP00000113975.2, ENSMUST00000120859.9

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79302054..79339779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245651.2 → XP_011243953.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_011243953.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159448.1 → XP_036015341.1 casein kinase I isoform X1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_011245652.3 → XP_011243954.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_011243954.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_011245653.4 → XP_011243955.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_011243955.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_017316657.2 → XP_017172146.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_006521043.4 → XP_006521106.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_006521106.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159446.1 → XP_036015339.1 casein kinase I isoform X1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159451.1 → XP_036015344.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_011245650.4 → XP_011243952.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_011243952.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_030248593.1 → XP_030104453.1 casein kinase I isoform X1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159447.1 → XP_036015340.1 casein kinase I isoform X1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_011245654.4 → XP_011243956.1 casein kinase I isoform X1

See identical proteins and their annotated locations for XP_011243956.1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159450.1 → XP_036015343.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159452.1 → XP_036015345.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_036159449.1 → XP_036015342.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_030248597.2 → XP_030104457.1 casein kinase I isoform X2

UniProtKB/Swiss-Prot

Q8R389, Q9JMK2

UniProtKB/TrEMBL

Q9QUI3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
XM_017316660.2 → XP_017172149.1 casein kinase I isoform X3

UniProtKB/TrEMBL

Q3TYE1

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon