Arl4c ADP-ribosylation factor-like 4C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arl4cprovided by MGI
Official Full Name: ADP-ribosylation factor-like 4Cprovided by MGI
Primary source: MGI:MGI:2445172
See related: Ensembl:ENSMUSG00000049866 AllianceGenome:MGI:2445172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LAK; Arl7; A630084M22Rik
Summary: Predicted to enable GTP binding activity and alpha-tubulin binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Orthologous to human ARL4C (ARF like GTPase 4C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 1 D; 1 44.85 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (88625947..88629913, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (88698225..88702191, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
Title: Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation.
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
Title: CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux
Title: MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
an important role of LXRs in the coordinated regulation of lipid metabolic and inflammatory gene programs in macrophages
Title: Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 4C

Names: ADP-ribosylation factor-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.