Nts neurotensin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntsprovided by MGI
Official Full Name: neurotensinprovided by MGI
Primary source: MGI:MGI:1328351
See related: Ensembl:ENSMUSG00000019890 AllianceGenome:MGI:1328351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NN; NT; NT/N; NTS1; NMN-125; 5033428E16Rik
Summary: Predicted to enable neuropeptide receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; neuropeptide signaling pathway; and visual learning. Predicted to be located in intracellular membrane-bounded organelle and neuronal cell body. Predicted to be active in axon terminus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; jaw; and retina. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human NTS (neurotensin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 17.8), large intestine adult (RPKM 7.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 53.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (102317617..102326294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (102481756..102490418, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides.
Title: Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides.
Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
Title: Neurotensin counteracts hair growth inhibition induced by chronic restraint stress.
Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
Title: Regulation of Atherosclerosis Development by Neurotensin Derived From Lymphatic Endothelial Cells in Mice.
Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
Title: Metabolitin regulates intestinal fat absorption via lymphatic endothelial cells derived neurotensin.
Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovarydagger.
Title: Neurotensin expression, regulation, and function during the ovulatory period in the mouse ovary†.
Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
Title: Neurotensin Release from Dopamine Neurons Drives Long-Term Depression of Substantia Nigra Dopamine Signaling.
Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
Title: Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.
Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
Title: Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord.
Effect of neurotensin on cultured mouse preimplantation embryos.
Title: Effect of neurotensin on cultured mouse preimplantation embryos.
Study found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated central amygdala (CeA) inhibitory inputs onto oval bed nucleus of the stria terminalis (ovBNST) neurons. NT and Dyn respectively increased and decreased CeA-toovBNST inhibitory inputs through NT receptor 1 and kappa opioid receptor. NT and Dyn mRNAs were highly co-localized in ovBNST neurons.
Title: Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide receptor binding	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurotensin/neuromedin N

Names: neuromedin N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429471.1 → NP_001416400.1 neurotensin/neuromedin N isoform 2

Status: VALIDATED

Source sequence(s)

AC131720
NM_024435.3 → NP_077755.1 neurotensin/neuromedin N isoform 1 precursor

See identical proteins and their annotated locations for NP_077755.1

Status: VALIDATED

Source sequence(s)

AC131720

Consensus CDS

CCDS24154.1

UniProtKB/Swiss-Prot

Q9D3P9

Related

ENSMUSP00000020040.4, ENSMUST00000020040.5

Conserved Domains (1) summary

pfam07421
Location:6 → 168

Pro-NT_NN; Neurotensin/neuromedin N precursor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

102317617..102326294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513992.4 → XP_006514055.1 neurotensin/neuromedin N isoform X1

Conserved Domains (1) summary

pfam07421
Location:1 → 129

Pro-NT_NN; Neurotensin/neuromedin N precursor