Wnk3 WNK lysine deficient protein kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnk3provided by RGD
Official Full Name: WNK lysine deficient protein kinase 3provided by RGD
Primary source: RGD:1563131
See related: EnsemblRapid:ENSRNOG00000002537 AllianceGenome:RGD:1563131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563131
Summary: Predicted to enable molecular condensate scaffold activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of pancreatic juice secretion; regulation of metal ion transport; and regulation of protein localization to plasma membrane. Predicted to act upstream of or within maintenance of blood-brain barrier. Predicted to be located in adherens junction and bicellular tight junction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Prieto syndrome. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 113.1), Brain (RPKM 55.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (23599278..23742290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (20156260..20299252)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (20316081..20459245)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
Title: WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
Title: Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
Title: LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_6238-6239:992007182:3 (e-PCR)
- UniSTS:231221

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables potassium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of cell volume homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of osmosensory signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase WNK3

NP_001157079.1

EC 2.7.11.1

NP_001398747.1

EC 2.7.11.1

XP_006256845.1

EC 2.7.11.1

XP_008771338.1

EC 2.7.11.1

XP_008771339.1

EC 2.7.11.1

XP_008771340.1

EC 2.7.11.1

XP_017457560.1

EC 2.7.11.1

XP_038955733.1

EC 2.7.11.1

XP_038955734.1

EC 2.7.11.1

XP_063136128.1

EC 2.7.11.1

XP_063136129.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163607.1 → NP_001157079.1 serine/threonine-protein kinase WNK3 isoform 2

See identical proteins and their annotated locations for NP_001157079.1

Status: PROVISIONAL

Source sequence(s)

CH474063

UniProtKB/TrEMBL

A6KLA2, D4A7Z8

Related

ENSRNOP00000042493.3, ENSRNOT00000047444.5

Conserved Domains (3) summary

smart00220
Location:151 → 404

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 462

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001411818.1 → NP_001398747.1 serine/threonine-protein kinase WNK3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A1W2Q671

Related

ENSRNOP00000076151.2, ENSRNOT00000093675.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

23599278..23742290

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280058.1 → XP_063136128.1 serine/threonine-protein kinase WNK3 isoform X4
XM_039099806.2 → XP_038955734.1 serine/threonine-protein kinase WNK3 isoform X1

UniProtKB/TrEMBL

A0A1W2Q671

Conserved Domains (2) summary

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 488

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_008773116.4 → XP_008771338.1 serine/threonine-protein kinase WNK3 isoform X2

Conserved Domains (3) summary

smart00220
Location:151 → 404

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 462

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_017602071.3 → XP_017457560.1 serine/threonine-protein kinase WNK3 isoform X3
XM_006256783.5 → XP_006256845.1 serine/threonine-protein kinase WNK3 isoform X1

See identical proteins and their annotated locations for XP_006256845.1

UniProtKB/TrEMBL

A0A1W2Q671

Conserved Domains (2) summary

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 488

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_008773118.4 → XP_008771340.1 serine/threonine-protein kinase WNK3 isoform X5

Conserved Domains (3) summary

smart00220
Location:151 → 404

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 462

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_063280059.1 → XP_063136129.1 serine/threonine-protein kinase WNK3 isoform X6

UniProtKB/TrEMBL

A0A0G2K2Y2

Related

ENSRNOP00000072423.2, ENSRNOT00000082177.3
XM_008773117.4 → XP_008771339.1 serine/threonine-protein kinase WNK3 isoform X4

Conserved Domains (3) summary

smart00220
Location:151 → 404

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 462

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_039099805.2 → XP_038955733.1 serine/threonine-protein kinase WNK3 isoform X1

UniProtKB/TrEMBL

A0A1W2Q671

Conserved Domains (2) summary

cd14031
Location:135 → 409

STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3

pfam12202
Location:425 → 488

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain