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    Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 399684, updated on 9-Dec-2024

    Summary

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    Symbol
    Vkorc1l1provided by RGD
    Full Name
    vitamin K epoxide reductase complex, subunit 1-like 1provided by RGD
    Primary source
    RGD:1303249
    See related
    EnsemblRapid:ENSRNOG00000083064 AllianceGenome:RGD:1303249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of RNA polymerase III complex. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 114.6), Brain (RPKM 106.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vkorc1l1 in Genome Data Viewer
    Location:
    12q12-q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32354078..32404327, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26717959..26768193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30218825..30268990, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA81 Neighboring gene ribosomal protein S9, pseudogene 15 Neighboring gene glucuronidase, beta Neighboring gene transfer RNA alanine (anticodon AGC) 84 Neighboring gene nuclear protein 2, transcriptional regulator Neighboring gene zinc finger BED-type containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration. Tie JK, et al. J Biol Chem, 2014 Mar 28. PMID 24532791, Free PMC Article
    2. Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. Westhofen P, et al. J Biol Chem, 2011 Apr 29. PMID 21367861, Free PMC Article
    3. VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. Hammed A, et al. J Biol Chem, 2013 Oct 4. PMID 23928358, Free PMC Article
    4. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Rost S, et al. Nature, 2004 Feb 5. PMID 14765194
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
      Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
    2. molecular cloning
      Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-glutamic acid carboxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-glutamic acid carboxylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin K metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vitamin K metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vitamin K metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vitamin K epoxide reductase complex subunit 1-like protein 1
    Names
    VKORC1-like protein 1
    NP_976083.1
    XP_017453907.2
    XP_038945585.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203338.1 → NP_976083.1  vitamin K epoxide reductase complex subunit 1-like protein 1

      See identical proteins and their annotated locations for NP_976083.1

      Status: VALIDATED

      Source sequence(s)
      AY423048
      UniProtKB/Swiss-Prot
      Q6TEK3
      Conserved Domains (1) summary
      cd12917
      Location:18 → 156
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32354078..32404327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598418.3 → XP_017453907.2  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWM1
      Related
      ENSRNOP00000100633.1, ENSRNOT00000122615.1

    2. XM_039089657.2 → XP_038945585.2  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TEK3.1 GenPept UniProtKB/Swiss-Prot:Q6TEK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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