Sumf2 sulfatase modifying factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sumf2provided by RGD
Full Name: sulfatase modifying factor 2provided by RGD
Primary source: RGD:1563253
See related: EnsemblRapid:ENSRNOG00000000922 AllianceGenome:RGD:1563253
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human SUMF2 (sulfatase modifying factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 423.2), Adrenal (RPKM 89.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32489671..32507941, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26853561..26871835, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30465025..30490683, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMF2 may mediate airway inflammation in allergic asthma by modulating the expression of IL-13
Title: Downregulation of SUMF2 gene in ovalbumin-induced rat model of allergic inflammation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134402 (e-PCR)
- UniSTS:217684

RH141366 (e-PCR)
- UniSTS:223362

RH138720 (e-PCR)
- UniSTS:220807

BF399653 (e-PCR)
- UniSTS:247751

BF387881 (e-PCR)
- UniSTS:244458

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive C-alpha-formylglycine-generating enzyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025125.2 → NP_001020296.2 inactive C-alpha-formylglycine-generating enzyme 2 precursor

See identical proteins and their annotated locations for NP_001020296.2

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/TrEMBL

A0A1W2Q645, A6J0P7

Related

ENSRNOP00000076122.3, ENSRNOT00000093294.3

Conserved Domains (2) summary

COG1262
Location:35 → 297

YfmG; Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones]

pfam03781
Location:35 → 297

FGE-sulfatase; Sulfatase-modifying factor enzyme 1