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    Socs7 suppressor of cytokine signaling 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Socs7provided by RGD
    Official Full Name
    suppressor of cytokine signaling 7provided by RGD
    Primary source
    RGD:1307720
    See related
    EnsemblRapid:ENSRNOG00000059008 AllianceGenome:RGD:1307720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within brain development; fat cell differentiation; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 157.9), Kidney (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Socs7 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82848525..82885201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82352159..82388829)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85301797..85337971)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 179 Neighboring gene dual specificity protein phosphatase 26 pseudogene Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC134480864 Neighboring gene SRC kinase signaling inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK, et al. Trends Endocrinol Metab, 2006 Nov. PMID 17010638
    2. Inhibitors of cytokine signal transduction. Wormald S, et al. J Biol Chem, 2004 Jan 9. PMID 14607831
    3. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. Banks AS, et al. J Clin Invest, 2005 Sep. PMID 16127460, Free PMC Article
    4. Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Simó S, et al. Dev Cell, 2013 Nov 25. PMID 24210661, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphorylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within layer formation in cerebral cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within radial glia guided migration of Purkinje cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427009.1 → NP_001413938.1  suppressor of cytokine signaling 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K9S1
      Related
      ENSRNOP00000075105.2, ENSRNOT00000080935.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82848525..82885201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087730.2 → XP_038943658.1  suppressor of cytokine signaling 7 isoform X2

      Conserved Domains (1) summary
      cd10388
      Location:450 → 550
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

    2. XM_039087731.2 → XP_038943659.1  suppressor of cytokine signaling 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGV0
      Conserved Domains (2) summary
      cd10388
      Location:381 → 481
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03741
      Location:505 → 553
      SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...

    3. XM_039087729.2 → XP_038943657.1  suppressor of cytokine signaling 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GM80
      Related
      ENSRNOP00000096744.1, ENSRNOT00000109410.2
      Conserved Domains (2) summary
      cd10388
      Location:416 → 516
      SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03741
      Location:540 → 588
      SOCS_SOCS7; SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal ...
    Nucleotide Protein Strain
    Heading Accession and Version

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