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    Sh3d19 SH3 domain containing 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295171, updated on 9-Dec-2024

    Summary

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    Symbol
    Sh3d19provided by RGD
    Full Name
    SH3 domain containing 19provided by RGD
    Primary source
    RGD:1304885
    See related
    EnsemblRapid:ENSRNOG00000011752 AllianceGenome:RGD:1304885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304885
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of membrane protein ectodomain proteolysis; and regulation of cell morphogenesis. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human SH3D19 (SH3 domain containing 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 155.2), Adrenal (RPKM 124.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3d19 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (173654234..173814030)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (171356244..171516042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (185268028..185431834)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L7a-like Neighboring gene cleavage and polyadenylation specific factor 3, pseudogene 1 Neighboring gene serine protease 48 Neighboring gene small nucleolar RNA, C/D box 73A Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. Tanaka M, et al. J Biol Chem, 2004 Oct 1. PMID 15280379
    2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein 19
    Names
    SH3 domain protein D19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433033.1 → NP_001419962.1  SH3 domain-containing protein 19 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A086, A0A8I6AB73

    2. NM_001433034.1 → NP_001419963.1  SH3 domain-containing protein 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZMF0, A0A8I6AB73

    RNA

    1. NR_197325.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NR_197326.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      173654234..173814030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232783.4 → XP_006232845.1  SH3 domain-containing protein 19 isoform X4

      See identical proteins and their annotated locations for XP_006232845.1

      UniProtKB/TrEMBL
      A0A8I6AB73
      Related
      ENSRNOP00000083936.2, ENSRNOT00000097494.2
      Conserved Domains (3) summary
      cd11816
      Location:850 → 900
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      cd11818
      Location:1015 → 1064
      SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
      cl17036
      Location:774 → 825
      SH3; Src Homology 3 domain superfamily

    2. XM_215597.11 → XP_215597.6  SH3 domain-containing protein 19 isoform X1

      Related
      ENSRNOP00000076208.3, ENSRNOT00000093640.3
      Conserved Domains (3) summary
      cd11816
      Location:850 → 900
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      cd11818
      Location:1009 → 1058
      SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
      cl17036
      Location:774 → 825
      SH3; Src Homology 3 domain superfamily

    3. XM_006232785.5 → XP_006232847.1  SH3 domain-containing protein 19 isoform X5

      See identical proteins and their annotated locations for XP_006232847.1

      UniProtKB/TrEMBL
      A0A8I6AB73
      Conserved Domains (3) summary
      cd11816
      Location:780 → 830
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      cd11818
      Location:945 → 994
      SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
      cl17036
      Location:704 → 755
      SH3; Src Homology 3 domain superfamily

    4. XM_063282714.1 → XP_063138784.1  SH3 domain-containing protein 19 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AB73
      Related
      ENSRNOP00000089094.2, ENSRNOT00000112954.2

    5. XM_039103745.2 → XP_038959673.1  SH3 domain-containing protein 19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AB73
      Related
      ENSRNOP00000079295.2, ENSRNOT00000095856.2
      Conserved Domains (4) summary
      cd11816
      Location:791 → 841
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      cd11818
      Location:956 → 1005
      SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:248 → 625
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:715 → 766
      SH3; Src Homology 3 domain superfamily

    6. XM_063282715.1 → XP_063138785.1  SH3 domain-containing protein 19 isoform X7

      UniProtKB/TrEMBL
      A6J5Z1
      Related
      ENSRNOP00000015803.5, ENSRNOT00000015802.8

    7. XM_039103746.2 → XP_038959674.1  SH3 domain-containing protein 19 isoform X3

      Related
      ENSRNOP00000095234.2, ENSRNOT00000106873.2
      Conserved Domains (4) summary
      cd11816
      Location:791 → 841
      SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
      cd11818
      Location:950 → 999
      SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
      PHA03247
      Location:248 → 625
      PHA03247; large tegument protein UL36; Provisional
      cl17036
      Location:715 → 766
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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