Enc1 ectodermal-neural cortex 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Enc1provided by RGD
Official Full Name: ectodermal-neural cortex 1provided by RGD
Primary source: RGD:1303152
See related: EnsemblRapid:ENSRNOG00000016541 AllianceGenome:RGD:1303152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nrpb
Summary: Involved in positive regulation of neuron projection development. Located in chromatin; neuronal cell body; and nuclear lumen. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 668.1), Heart (RPKM 77.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (30285274..30297194)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (28550670..28562591)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (28049217..28061023)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Enc1 protects neurons from apoptosis induced by oxygen-glucose deprivation associated with Nrf2 and HO-1.
Title: Inhibition of Ectodermal-Neural Cortex 1 Protects Neural Cells from Apoptosis Induced by Hypoxia and Hypoglycemia.
show that overexpression of the Nrp/b cDNA in C6/ST1 cells suppresses anchorage independence in vitro and tumorigenicity in vivo, altering their malignant nature towards a more benign phenotype.
Title: Overexpression of Nrp/b (nuclear restrict protein in brain) suppresses the malignant phenotype in the C6/ST1 glioma cell line.
The study further shows the physical association of ENC1 and F-actin, implicating the role of ENC1 in cytoskeletal reorganization during the differentiation of granulosa cells.
Title: Expression of ectodermal neural cortex 1 and its association with actin during the ovulatory process in the rat.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasomal ubiquitin-independent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ectoderm-neural cortex protein 1

Names: nuclear restrict protein in brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003401.2 → NP_001003401.1 ectoderm-neural cortex protein 1

See identical proteins and their annotated locations for NP_001003401.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5Y5L9, Q2V9T0, Q6DKY8

Related

ENSRNOP00000022144.3, ENSRNOT00000022144.7

Conserved Domains (6) summary

smart00612
Location:389 → 441

Kelch; Kelch domain

PHA03098
Location:48 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:330 → 374

Kelch; KELCH repeat [structural motif]

pfam00651
Location:36 → 140

BTB; BTB/POZ domain

pfam01344
Location:329 → 374

Kelch_1; Kelch motif

pfam07707
Location:149 → 251

BACK; BTB And C-terminal Kelch