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    Sec14l1 SEC14-like lipid binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec14l1provided by RGD
    Official Full Name
    SEC14-like lipid binding 1provided by RGD
    Primary source
    RGD:1563123
    See related
    EnsemblRapid:ENSRNOG00000002722 AllianceGenome:RGD:1563123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563123
    Summary
    Predicted to enable RIG-I binding activity and protein sequestering activity. Predicted to be involved in choline transport and negative regulation of RIG-I signaling pathway. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Orthologous to human SEC14L1 (SEC14 like lipid binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 201.0), Adrenal (RPKM 168.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec14l1 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102818693..102865841)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102319920..102367070)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106065712..106112859)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC100912002 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene ribosomal protein L12, pseudogene 9 Neighboring gene uncharacterized LOC102547461 Neighboring gene septin 9 Neighboring gene uncharacterized LOC134480908 Neighboring gene uncharacterized LOC134480724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. Li MT, et al. J Virol, 2013 Sep. PMID 23843640, Free PMC Article
    2. SEC14-like protein 1 interacts with cholinergic transporters. Ribeiro FM, et al. Neurochem Int, 2007 Jan. PMID 17092608
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RIG-I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RIG-I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 1
    Names
    SEC14-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108309.1 → NP_001101779.1  SEC14-like protein 1

      See identical proteins and their annotated locations for NP_001101779.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I5ZQG0, A6HL08, D3ZKG3
      Related
      ENSRNOP00000080746.1, ENSRNOT00000117738.2
      Conserved Domains (3) summary
      smart01100
      Location:257 → 302
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:327 → 491
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:17 → 173
      PRELI; PRELI-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102818693..102865841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269479.1 → XP_063125549.1  SEC14-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQG0, A0A8I5ZVS7
      Related
      ENSRNOP00000003690.5, ENSRNOT00000003690.7

    2. XM_017597412.3 → XP_017452901.1  SEC14-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQG0, A6HL08, D3ZKG3
      Conserved Domains (3) summary
      smart01100
      Location:257 → 302
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:327 → 491
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:17 → 173
      PRELI; PRELI-like family
    Nucleotide Protein Strain
    Heading Accession and Version

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