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    Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245903, updated on 9-Dec-2024

    Summary

    Official Symbol
    Magi3provided by RGD
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 3provided by RGD
    Primary source
    RGD:621362
    See related
    EnsemblRapid:ENSRNOG00000019885 AllianceGenome:RGD:621362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slipr
    Summary
    Enables protein phosphatase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Predicted to be located in cell junction. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 243.5), Heart (RPKM 144.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Magi3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194206587..194405468, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191514726..191717048, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206499467..206699105, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene round spermatid basic protein 1 Neighboring gene uncharacterized LOC134485663 Neighboring gene putative homeodomain transcription factor 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485759 Neighboring gene uncharacterized LOC108350079 Neighboring gene ribosomal protein L17, pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
    Names
    MAGI-3
    membrane-associated guanylate kinase inverted 3
    membrane-associated guanylate kinase-related (MAGI-3)
    scaffolding protein SLIPR
    scaffolding-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139084.3NP_620784.3  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JK71
      UniProtKB/TrEMBL
      F1M7S0
      Related
      ENSRNOP00000026952.5, ENSRNOT00000026952.8
      Conserved Domains (6) summary
      smart00228
      Location:729812
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG5021
      Location:211373
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00201
      Location:299329
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:10231101
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00112
      Location:11151405
      PTZ00112; origin recognition complex 1 protein; Provisional
      cl17190
      Location:125199
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194206587..194405468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101721.2XP_038957649.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9JK71
      Conserved Domains (6) summary
      smart00228
      Location:711794
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG5021
      Location:211373
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00201
      Location:299329
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:10051083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PTZ00112
      Location:10971387
      PTZ00112; origin recognition complex 1 protein; Provisional
      cl17190
      Location:125199
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_008761367.4XP_008759589.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_008759589.1

      UniProtKB/TrEMBL
      A0A8I6AE46
      Related
      ENSRNOP00000090602.1, ENSRNOT00000098245.2
      Conserved Domains (4) summary
      smart00456
      Location:297329
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:729812
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:10231101
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17190
      Location:125199
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...