Ipo5 importin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ipo5provided by RGD
Official Full Name: importin 5provided by RGD
Primary source: RGD:1308715
See related: EnsemblRapid:ENSRNOG00000010989 AllianceGenome:RGD:1308715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kpnb3; Ranbp5
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in several processes, including cytoplasmic pattern recognition receptor signaling pathway; positive regulation of protein import into nucleus; and protein import into nucleus. Predicted to be located in Golgi apparatus; cytosol; and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human IPO5 (importin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 1000.6), Muscle (RPKM 485.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (104397626..104447985)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (97990755..98041074)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (106243110..106293326)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

C76941 (e-PCR)
- UniSTS:160895

RH130384 (e-PCR)
- UniSTS:213668

RH140893 (e-PCR)
- UniSTS:222909

RH126066 (e-PCR)
- UniSTS:162778

RH133768 (e-PCR)
- UniSTS:217051

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: importin-5

Names: RAN binding protein 5; karyopherin (importin) beta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427143.1 → NP_001414072.1 importin-5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

D4A781

Related

ENSRNOP00000014859.5, ENSRNOT00000014859.10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

104397626..104447985

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093991.2 → XP_038949919.1 importin-5 isoform X2

UniProtKB/TrEMBL

D4A781

Related

ENSRNOP00000100865.1, ENSRNOT00000147249.1

Conserved Domains (6) summary

COG5215
Location:13 → 634

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:355 → 387

HEAT; HEAT repeat [structural motif]

pfam13513
Location:921 → 966

HEAT_EZ; HEAT-like repeat

pfam18808
Location:268 → 357

Importin_rep_4; Importin repeat

pfam18816
Location:1005 → 1051

Importin_rep_5; Importin repeat

pfam18829
Location:765 → 874

Importin_rep_6; Importin repeat 6
XM_017599929.3 → XP_017455418.1 importin-5 isoform X2

UniProtKB/TrEMBL

D4A781

Related

ENSRNOP00000103867.1, ENSRNOT00000168416.1

Conserved Domains (6) summary

COG5215
Location:13 → 634

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:355 → 387

HEAT; HEAT repeat [structural motif]

pfam13513
Location:921 → 966

HEAT_EZ; HEAT-like repeat

pfam18808
Location:268 → 357

Importin_rep_4; Importin repeat

pfam18816
Location:1005 → 1051

Importin_rep_5; Importin repeat

pfam18829
Location:765 → 874

Importin_rep_6; Importin repeat 6
XM_224534.11 → XP_224534.8 importin-5 isoform X2

UniProtKB/TrEMBL

D4A781

Related

ENSRNOP00000099992.1, ENSRNOT00000161845.1

Conserved Domains (6) summary

COG5215
Location:13 → 634

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:355 → 387

HEAT; HEAT repeat [structural motif]

pfam13513
Location:921 → 966

HEAT_EZ; HEAT-like repeat

pfam18808
Location:268 → 357

Importin_rep_4; Importin repeat

pfam18816
Location:1005 → 1051

Importin_rep_5; Importin repeat

pfam18829
Location:765 → 874

Importin_rep_6; Importin repeat 6
XM_063274353.1 → XP_063130423.1 importin-5 isoform X1

Related

ENSRNOP00000100599.1, ENSRNOT00000130047.1
XM_063274354.1 → XP_063130424.1 importin-5 isoform X2

UniProtKB/TrEMBL

D4A781
XM_063274355.1 → XP_063130425.1 importin-5 isoform X3

UniProtKB/TrEMBL

M0RB74