Slco3a1 solute carrier organic anion transporter family, member 3a1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco3a1provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 3a1provided by RGD
Primary source: RGD:620227
See related: EnsemblRapid:ENSRNOG00000032798 AllianceGenome:RGD:620227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slc21a11
Summary: Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in prostaglandin transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 55.4), Lung (RPKM 41.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (137516037..137797836, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (128106232..128388043, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (135790854..136073640, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

plays an important role in translocating prostaglandins in specialized tissues and cells.
Title: Molecular characterization of human and rat organic anion transporter OATP-D.

Submit: New GeneRIF Correction

General gene information

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Markers

Slco3a1 (e-PCR), detects polymorphism
- UniSTS:547142

D1Got113 (e-PCR)
- UniSTS:115038

D1Mco53 (e-PCR)
- UniSTS:518494

BF387901 (e-PCR)
- UniSTS:244465

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 3A1

Names: OATP-D; organic anion-transporting polypeptide D; prostaglandin transporter subtype 2; sodium-independent organic anion transporter D; solute carrier family 21 (organic anion transporter), member 11; solute carrier family 21 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.