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    Adgra2 adhesion G protein-coupled receptor A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100363275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgra2provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor A2provided by RGD
    Primary source
    RGD:2323365
    See related
    EnsemblRapid:ENSRNOG00000012991 AllianceGenome:RGD:2323365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr124
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and sprouting angiogenesis. Predicted to act upstream of or within several processes, including negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of endothelial cell migration; and regulation of establishment of blood-brain barrier. Predicted to be located in cell surface and intracellular membrane-bounded organelle. Predicted to be part of Wnt signalosome. Predicted to be active in plasma membrane. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 117.3), Uterus (RPKM 103.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgra2 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71635814..71674275, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64932964..64971433, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69094587..69133015, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene RAB11 family interacting protein 1 Neighboring gene BRF2 general transcription factor 3B subunit Neighboring gene uncharacterized LOC134482405 Neighboring gene uncharacterized LOC134482406 Neighboring gene uncharacterized LOC120097504 Neighboring gene pyridoxal phosphate binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury. Xu Y, et al. Eur J Pharmacol, 2024 Jan 5. PMID 38042462
    2. Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat. Calderón-Zamora L, et al. Clin Exp Hypertens, 2017. PMID 28678544
    3. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Chang J, et al. Nat Med, 2017 Apr. PMID 28288111, Free PMC Article
    4. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Kuhnert F, et al. Science, 2010 Nov 12. PMID 21071672, Free PMC Article
    5. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Cho C, et al. Neuron, 2017 Aug 30. PMID 28803732, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
      Title: GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
    2. Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure.
      Title: Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Wnt signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Wnt signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor A2
    Names
    G protein-coupled receptor 124

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433282.1 → NP_001420211.1  adhesion G protein-coupled receptor A2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVY1, D4ADC7

    2. NM_001433283.1 → NP_001420212.1  adhesion G protein-coupled receptor A2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6G7Z0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      71635814..71674275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275883.1 → XP_063131953.1  adhesion G protein-coupled receptor A2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G7Z0, A0A8I6GIV5
      Related
      ENSRNOP00000090414.1, ENSRNOT00000109034.2

    2. XM_017600376.3 → XP_017455865.1  adhesion G protein-coupled receptor A2 isoform X2

      UniProtKB/TrEMBL
      D4ADC7
      Related
      ENSRNOP00000017776.6, ENSRNOT00000017776.7

    3. XM_003751617.6 → XP_003751665.2  adhesion G protein-coupled receptor A2 isoform X1

      Related
      ENSRNOP00000081432.2, ENSRNOT00000096010.2
      Conserved Domains (8) summary
      smart00082
      Location:234 → 267
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:130 → 208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:130 → 151
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:299 → 385
      ig; Immunoglobulin domain
      pfam01825
      Location:750 → 791
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:130 → 186
      LRR_8; Leucine rich repeat
      cl02422
      Location:393 → 459
      HRM; Hormone receptor domain
      cl21561
      Location:817 → 985
      7tm_4; Olfactory receptor

    4. XM_006253295.5 → XP_006253357.1  adhesion G protein-coupled receptor A2 isoform X3

      Conserved Domains (8) summary
      smart00082
      Location:234 → 267
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:130 → 208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:130 → 151
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:299 → 385
      ig; Immunoglobulin domain
      pfam01825
      Location:750 → 791
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:130 → 186
      LRR_8; Leucine rich repeat
      cl02422
      Location:393 → 459
      HRM; Hormone receptor domain
      cl21561
      Location:817 → 985
      7tm_4; Olfactory receptor

    5. XM_039095155.2 → XP_038951083.1  adhesion G protein-coupled receptor A2 isoform X5

      Conserved Domains (9) summary
      COG4886
      Location:118 → 349
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:130 → 151
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:750 → 791
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:130 → 186
      LRR_8; Leucine rich repeat
      cd00096
      Location:343 → 347
      Ig; Ig strand D [structural motif]
      cd14964
      Location:807 → 832
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02422
      Location:393 → 459
      HRM; Hormone receptor domain
      cl11960
      Location:338 → 385
      Ig; Immunoglobulin domain
      cl28897
      Location:805 → 876
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_005494961.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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