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    Asmtl acetylserotonin O-methyltransferase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asmtlprovided by RGD
    Official Full Name
    acetylserotonin O-methyltransferase-likeprovided by RGD
    Primary source
    RGD:1306877
    See related
    EnsemblRapid:ENSRNOG00000028166 AllianceGenome:RGD:1306877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleoside triphosphate diphosphatase activity. Predicted to be located in cytosol. Orthologous to human ASMTL (acetylserotonin O-methyltransferase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 111.7), Heart (RPKM 88.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asmtl in Genome Data Viewer
    Location:
    12q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21429119..21431847)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16315335..16318083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18532090..18534761)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene acetylserotonin O-methyltransferase Neighboring gene A-kinase anchoring protein 17A Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene pumilio RNA-binding family member 3, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleoside triphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylserotonin O-methyltransferase-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105915.2 → NP_001099385.2  N-acetylserotonin O-methyltransferase-like protein

      Status: VALIDATED

      Source sequence(s)
      BP484213, FM052956, FM053536, FM067394
      UniProtKB/TrEMBL
      A0A8I5ZM76, D4AA35
      Related
      ENSRNOP00000038215.5, ENSRNOT00000036606.8
      Conserved Domains (1) summary
      cd00555
      Location:15 → 209
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      21429119..21431847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089199.2 → XP_038945127.1  N-acetylserotonin O-methyltransferase-like protein isoform X2

      Conserved Domains (1) summary
      cl00276
      Location:15 → 129
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...

    2. XM_006249001.4 → XP_006249063.1  N-acetylserotonin O-methyltransferase-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM76, A0A8I6AKB0
      Related
      ENSRNOP00000095718.1, ENSRNOT00000108870.2
      Conserved Domains (1) summary
      cd00555
      Location:15 → 246
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...

    3. XM_039089200.2 → XP_038945128.1  N-acetylserotonin O-methyltransferase-like protein isoform X3

      UniProtKB/TrEMBL
      A6K208
      Conserved Domains (1) summary
      cl00276
      Location:1 → 117
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...

    4. XM_039089202.2 → XP_038945130.1  N-acetylserotonin O-methyltransferase-like protein isoform X3

      UniProtKB/TrEMBL
      A6K208
      Conserved Domains (1) summary
      cl00276
      Location:1 → 117
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...

    5. XM_039089203.2 → XP_038945131.1  N-acetylserotonin O-methyltransferase-like protein isoform X3

      UniProtKB/TrEMBL
      A6K208
      Conserved Domains (1) summary
      cl00276
      Location:1 → 117
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...

    6. XM_039089201.2 → XP_038945129.1  N-acetylserotonin O-methyltransferase-like protein isoform X3

      UniProtKB/TrEMBL
      A6K208
      Conserved Domains (1) summary
      cl00276
      Location:1 → 117
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...

    RNA

    1. XR_010056370.1 RNA Sequence

    2. XR_005491610.2 RNA Sequence

    3. XR_005491611.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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