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    Tmem9 transmembrane protein 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem9provided by RGD
    Official Full Name
    transmembrane protein 9provided by RGD
    Primary source
    RGD:1307922
    See related
    EnsemblRapid:ENSRNOG00000010204 AllianceGenome:RGD:1307922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 123.8), Brain (RPKM 118.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem9 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50008829..50027556)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47458486..47475832)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52854031..52871300)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene uncharacterized LOC134481564

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. Kveine M, et al. Biochem Biophys Res Commun, 2002 Oct 4. PMID 12359240
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton-transporting V-type ATPase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proton-transporting V-type ATPase complex assembly regulator TMEM9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105953.2 → NP_001099423.2  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

      See identical proteins and their annotated locations for NP_001099423.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC169086, JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JUD1, A0A8J8YFY6, A6ICH5, B5DFJ7, F7F2S9
      Conserved Domains (1) summary
      pfam05434
      Location:44 → 182
      Tmemb_9; TMEM9

    2. NM_001277263.1 → NP_001264192.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

      See identical proteins and their annotated locations for NP_001264192.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC169086, JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JUD1, A0A8J8YFY6, A6ICH5, B5DFJ7, F7F2S9
      Related
      ENSRNOP00000013738.8, ENSRNOT00000013738.8
      Conserved Domains (1) summary
      pfam05434
      Location:44 → 182
      Tmemb_9; TMEM9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50008829..50027556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272090.1 → XP_063128160.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUD1, A0A8J8YFY6, A6ICH5, B5DFJ7, F7F2S9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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