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    Cert1 ceramide transporter 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cert1provided by RGD
    Official Full Name
    ceramide transporter 1provided by RGD
    Primary source
    RGD:1309131
    See related
    EnsemblRapid:ENSRNOG00000015686 AllianceGenome:RGD:1309131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Col4a3bp
    Summary
    Predicted to enable several functions, including ceramide transfer activity; identical protein binding activity; and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane sphingolipid transfer. Predicted to act upstream of or within several processes, including ceramide metabolic process; in utero embryonic development; and lipid homeostasis. Predicted to be located in several cellular components, including Golgi apparatus; nucleoplasm; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 192.5), Adrenal (RPKM 183.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cert1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (29617202..29721734)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27882546..27987090)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27365145..27469797)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene DNA polymerase kappa Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene ankyrin repeat domain 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide binding  
    enables ceramide transfer activity  
    enables identical protein binding  
    enables kinase activity  
    enables phosphatidylinositol-4-phosphate binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in membrane  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    ceramide transfer protein
    Names
    alpha 3 type IV collagen binding protein
    collagen type IV alpha 3 binding protein
    collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
    procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
    NP_001102405.1
    XP_006231889.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108935.1NP_001102405.1  ceramide transfer protein

      See identical proteins and their annotated locations for NP_001102405.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473955
      UniProtKB/TrEMBL
      A6I509, D4ACN6
      Related
      ENSRNOP00000021549.6, ENSRNOT00000021549.7
      Conserved Domains (3) summary
      cd08872
      Location:391624
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:26125
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
      pfam00169
      Location:24114
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      29617202..29721734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231827.5XP_006231889.1  ceramide transfer protein isoform X1

      See identical proteins and their annotated locations for XP_006231889.1

      UniProtKB/TrEMBL
      A0A8I5ZRB1, A6I510
      Related
      ENSRNOP00000080901.1, ENSRNOT00000110704.2
      Conserved Domains (3) summary
      cd08872
      Location:364598
      START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
      cd13283
      Location:26125
      PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
      pfam00169
      Location:24114
      PH; PH domain
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