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    Ddx20 DEAD-box helicase 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddx20provided by RGD
    Official Full Name
    DEAD-box helicase 20provided by RGD
    Primary source
    RGD:621744
    See related
    EnsemblRapid:ENSRNOG00000015274 AllianceGenome:RGD:621744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dp103
    Summary
    Enables protein domain specific binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of cell population proliferation. Predicted to be located in cytosol and nuclear body. Predicted to be part of RNA polymerase II transcription repressor complex and SMN complex. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 240.4), Thymus (RPKM 90.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx20 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (195847105..195859989, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193158761..193168484, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208144142..208154764, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691662 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene uncharacterized LOC134485946 Neighboring gene inka box actin regulator 2 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene RAP1A, member of RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function. Mouillet JF, et al. Endocrinology, 2008 May. PMID 18258677, Free PMC Article
    2. The DEAD box protein DP103 is a regulator of steroidogenic factor-1. Ou Q, et al. Mol Endocrinol, 2001 Jan. PMID 11145740
    3. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Lee K, et al. Biochem Biophys Res Commun, 2005 Oct 28. PMID 16153597
    4. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
    5. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Klappacher GW, et al. Cell, 2002 Apr 19. PMID 12007404

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX20
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
    NP_001178640.1
    XP_006233161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191711.1 → NP_001178640.1  probable ATP-dependent RNA helicase DDX20

      See identical proteins and their annotated locations for NP_001178640.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1MAM8
      Conserved Domains (3) summary
      PRK01297
      Location:9 → 441
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      pfam00271
      Location:294 → 404
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:64 → 265
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      195847105..195859989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233099.5 → XP_006233161.1  probable ATP-dependent RNA helicase DDX20 isoform X1

      See identical proteins and their annotated locations for XP_006233161.1

      UniProtKB/TrEMBL
      F1MAM8
      Related
      ENSRNOP00000062813.1, ENSRNOT00000068152.5
      Conserved Domains (3) summary
      PRK01297
      Location:9 → 441
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      pfam00271
      Location:294 → 404
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:64 → 265
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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