Myo1c myosin 1C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo1cprovided by RGD
Official Full Name: myosin 1Cprovided by RGD
Primary source: RGD:620443
See related: EnsemblRapid:ENSRNOG00000004072 AllianceGenome:RGD:620443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MMIb; Myr2; MMI-beta
Summary: Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 638.1), Heart (RPKM 586.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60996642..61019022)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (60498372..60520752)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63803311..63819614)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C.
Title: SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C.
this paper shows that inhibition of myosin 1c reduced exocytosis in alveolar type II cells
Title: The role of myosin 1c and myosin 1b in surfactant exocytosis.
Interaction of vesicular Myo1c with cortical actin filaments is required for insulin-mediated tethering of GLUT4 vesicles and for efficient GLUT4 surface delivery in muscle cells.
Title: Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles.
CIB1 and CaBP1 bind to the myo1c IQ motifs in the regulatory domain where they compete with calmodulin for binding; it is proposed that these proteins may play a role in specifying subcellular localization of myo1c
Title: CIB1 and CaBP1 bind to the myo1c regulatory domain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along actin filament	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along actin filament	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium bundle	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium membrane	IEA Inferred from Electronic Annotation more info
NOT located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Ic

Names: myosin I beta; myosin IC; myosin IC-like; myosin heavy chain myr 2; myosin-Ic; unconventional myosin Myr2 I heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414168.1 → NP_001401097.1 unconventional myosin-Ic isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZQN4, A0A8I6ASB9

Related

ENSRNOP00000097261.1, ENSRNOT00000101210.2
NM_023092.3 → NP_075580.2 unconventional myosin-Ic isoform 2

See identical proteins and their annotated locations for NP_075580.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q63355

UniProtKB/TrEMBL

A0A8I5ZQN4

Related

ENSRNOP00000028929.7, ENSRNOT00000036666.7

Conserved Domains (4) summary

smart00015
Location:737 → 757

IQ; Calmodulin-binding motif

smart00242
Location:24 → 709

MYSc; Myosin. Large ATPases

cd01378
Location:43 → 699

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:855 → 1022

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

60996642..61019022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086809.1 → XP_038942737.1 unconventional myosin-Ic isoform X2

UniProtKB/TrEMBL

A0A8I5ZQN4

Related

ENSRNOP00000102184.1, ENSRNOT00000155184.1

Conserved Domains (3) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1020

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_063269827.1 → XP_063125897.1 unconventional myosin-Ic isoform X1

UniProtKB/TrEMBL

A0A8I5ZQN4, A0A8I6AQB5

Related

ENSRNOP00000096158.1, ENSRNOT00000117022.2
XM_039086811.2 → XP_038942739.1 unconventional myosin-Ic isoform X3

UniProtKB/TrEMBL

A0A8I5ZQN4, A0A8L2QFL2

Related

ENSRNOP00000080420.1, ENSRNOT00000108756.2

Conserved Domains (3) summary

smart00015
Location:678 → 698

IQ; Calmodulin-binding motif

cd01378
Location:39 → 640

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:796 → 977

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding