Cldn3 claudin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cldn3provided by RGD
Official Full Name: claudin 3provided by RGD
Primary source: RGD:68425
See related: EnsemblRapid:ENSRNOG00000046007 AllianceGenome:RGD:68425
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Involved in response to Gram-positive bacterium and response to ethanol. Located in bicellular tight junction and lateral plasma membrane. Biomarker of peptic esophagitis. Orthologous to human CLDN3 (claudin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27345075..27346547, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21708538..21710010, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (21831341..21832813, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified four claudin isoforms (1, 3, 5, and 12) and showed that their expression levels were regulated as a group by copper
Title: The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress.
Colonic glands without a fecal stream showed a reduction in claudin-3 content independent of the time and reduction in occludin content after 12 weeks of intestinal exclusion.
Title: Claudin-3 and occludin tissue content in the glands of colonic mucosa with and without a fecal stream.
Esophageal and laryngeal expressions of claudin-3 were significantly lower in rats with surgically induced laryngopharyngeal reflux.
Title: Expression of claudin-3 in the esophagus and larynx of rat reflux model.
therapeutic effect of neurotensin on the disruption of the intestinal barrier is associated with claudin-3 alteration
Title: Claudin-3 expression in radiation-exposed rat models: a potential marker for radiation-induced intestinal barrier failure.
tight junction proteins Cldn 1,3 and 5 show altered distribution after intestinal ischaemia/reperfusion injury in rats
Title: Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats.
claudin-3 on the esophageal epithelial plasma membrane could be a specific and sensitive indicator suitable for monitoring inflammatory and recovery processes in reflux esophagitis
Title: Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease.
These results demonstrate that, in the context of the alveolar epithelium, Cldn-3 and Cldn-4 have different effects on paracellular permeability, despite significant homology in their extracellular loop domains.
Title: Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function.
Hemorrhagic shock causes an acute rise in serum claudin-3 protein levels and a concurrent decrease in intestinal claudin-3 protein expression.
Title: Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment.
Here we show for the first time in both an experimental and clinical setting a strong relation between intestinal tight junction loss and urinary claudin-3 levels
Title: Urine-based detection of intestinal tight junction loss.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH144525 (e-PCR)
- UniSTS:233770

RH139762 (e-PCR)
- UniSTS:221846

Cldn3 (e-PCR), detects polymorphism
- UniSTS:465377

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of endothelial blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: claudin-3

Names: RVP1; ventral prostate.1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.