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    DMT2 DNA methyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827052, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DMT2
    Official Full Name
    DNA methyltransferase 2
    Primary source
    TAIR:AT4G14140
    Locus tag
    AT4G14140
    See related
    Araport:AT4G14140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DL3110W; DMT02; DNA METHYLTRANSFERASE 02; DNA methyltransferase 2; DNA METHYLTRANSFERASE 2; FCAALL.111; MET02; MET2
    Summary
    This gene is predicted to encode a DNA methyltransferase. A plant line expressing an RNAi construct directed against DMT2 has reduced agrobacterium-mediated tumor formation.
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    Genomic context

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    See DMT2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (8145998..8152131)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene xyloglucan endotransglucosylase/hydrolase 15 Neighboring gene miscRNA Neighboring gene cytochrome C oxidase assembly protein Neighboring gene binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi-mediated gene silencing reveals involvement of Arabidopsis chromatin-related genes in Agrobacterium-mediated root transformation. Crane YM, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17827277, Free PMC Article
    2. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203796.1
    NM_001340902.1
    NM_117491.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-mediated transformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA methyltransferase 2
    NP_001190725.1
    • DNA methyltransferase 2 (DMT2); FUNCTIONS IN: DNA binding, DNA (cytosine-5-)-methyltransferase activity; INVOLVED IN: DNA mediated transformation, DNA methylation; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: DNA (cytosine-5)-methyltransferase 1 (InterPro:IPR017198), DNA methylase, C-5 cytosine-specific (InterPro:IPR001525), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), DNA methylase, C-5 cytosine-specific, active site (InterPro:IPR018117); BEST Arabidopsis thaliana protein match is: DNA (cytosine-5-)-methyltransferase family protein (TAIR:AT4G08990.1).
    NP_001319931.1
    • DNA methyltransferase 2 (DMT2); FUNCTIONS IN: DNA binding, DNA (cytosine-5-)-methyltransferase activity; INVOLVED IN: DNA mediated transformation, DNA methylation; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: DNA (cytosine-5)-methyltransferase 1 (InterPro:IPR017198), DNA methylase, C-5 cytosine-specific (InterPro:IPR001525), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), DNA methylase, C-5 cytosine-specific, active site (InterPro:IPR018117); BEST Arabidopsis thaliana protein match is: DNA (cytosine-5-)-methyltransferase family protein (TAIR:AT4G08990.1); Has 6837 Blast hits to 5882 proteins in 1415 species: Archae - 242; Bacteria - 4316; Metazoa - 345; Fungi - 236; Plants - 327; Viruses - 89; Other Eukaryotes - 1282 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8145998..8152131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340902.1 → NP_001319931.1  DNA methyltransferase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JUL5, O23273, Q9SEG3
      UniProtKB/TrEMBL
      A0A654FP76

    2. NM_001203796.1 → NP_001190725.1  DNA methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FP76
      Conserved Domains (4) summary
      cd04708
      Location:884 → 1090
      BAH_plantDCM_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects ...
      pfam12047
      Location:368 → 519
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
      cl02608
      Location:722 → 850
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
      cl17173
      Location:1078 → 1533
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_117491.1 → NP_193150.1  DNA methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JUL5, O23273, Q9SEG3
      UniProtKB/TrEMBL
      A0A654FP76
      Conserved Domains (4) summary
      cd04708
      Location:884 → 1090
      BAH_plantDCM_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects ...
      pfam12047
      Location:368 → 519
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain
      cl02608
      Location:722 → 850
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
      cl17173
      Location:1078 → 1507
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23273.1

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