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    Pfdn5 Prefoldin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42647, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pfdn5provided by FlyBase
    Official Full Name
    Prefoldin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038976
    Locus tag
    Dmel_CG7048
    See related
    AllianceGenome:FB:FBgn0038976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7048; Dmel\CG7048; pfdn5
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding and protein-containing complex assembly. Part of prefoldin complex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and somatic trunk mesoderm derivative. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pfdn5 in Genome Data Viewer
    Location:
    94B1-94B1; 3-75 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22487039..22488110)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18312761..18313832)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 1 Neighboring gene testis-enriched HMG-box-containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A microtubule polymerase is required for microtubule orientation and dendrite pruning in Drosophila. Tang Q, et al. EMBO J, 2020 May 18. PMID 32267553, Free PMC Article
    2. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
    3. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    4. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article
    5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II core complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin 5
    Names
    CG7048-PA
    CG7048-PB
    Pfdn5-PA
    Pfdn5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22487039..22488110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170217.2 → NP_001163688.1  prefoldin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163688.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCZ8
      UniProtKB/TrEMBL
      E1JIT4
      Conserved Domains (1) summary
      cd00584
      Location:21 → 149
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

    2. NM_142796.4 → NP_651053.1  prefoldin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCZ8
      UniProtKB/TrEMBL
      E1JIT4
      Related
      FBpp0083650
      Conserved Domains (1) summary
      cd00584
      Location:21 → 149
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIT4 E1JIT4
    Q9VCZ8.1 Q9VCZ8

    Gene LinkOut

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