U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    al aristaless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33208, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    alprovided by FlyBase
    Official Full Name
    aristalessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000061
    Locus tag
    Dmel_CG3935
    See related
    AllianceGenome:FB:FBgn0000061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A1; Al; AL; CG3935; Dmel\CG3935; L13-4; lambda13-4
    Summary
    Contributes to sequence-specific DNA binding activity. Involved in chaeta development; imaginal disc-derived appendage morphogenesis; and negative regulation of DNA-templated transcription. Part of protein-containing complex. Is expressed in several structures, including gut section; imaginal disc; organism subdivision; sense organ; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in X-linked lissencephaly 2; X-linked recessive disease (multiple); corpus callosum agenesis-abnormal genitalia syndrome; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ARX (aristaless related homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    21C1-21C1; 2-0.7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (378112..387439)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (378112..387439)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45367 Neighboring gene antisense RNA:CR45366 Neighboring gene Equilibrative nucleoside transporter 1 Neighboring gene long non-coding RNA:CR43718 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Schneitz K, et al. Genes Dev, 1993 Jan. PMID 8093690
    2. Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. Miyazono K, et al. EMBO J, 2010 May 5. PMID 20389279, Free PMC Article
    3. Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development. Dornan S, et al. Mol Biol Cell, 1997 Aug. PMID 9285813, Free PMC Article
    4. The function and processing of auditory information in the courtship behaviour of Drosophila melanogaster. Burnet B, et al. Anim Behav, 1971 May. PMID 5004809
    5. Molecular dynamics simulations show altered secondary structure of clawless in binary complex with DNA providing insights into aristaless-clawless-DNA ternary complex formation. Kachhap S, et al. J Biomol Struct Dyn, 2017 May. PMID 27058822

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the Al-Cll-DNA complex structure, the residues in the extended regions are used not only for the intermolecular contacts between the two homeodomain proteins but also for the sequence-recognition mechanism of DNA by direct interactions.
      Title: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.
    2. Data show that Aristaless and Clawless proteins form a complex capable of binding to specific DNA targets, which cannot be well recognized solely by Aristaless or Clawless.
      Title: A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg.
    3. homeodomain proteins Bar and Aristaless and the LIM-HOM proteins Apterous and Lim1 regulate distal leg development
      Title: Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antennal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in elongation of arista core IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    aristaless
    Names
    CG3935-PA
    al-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      378112..387439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164382.2 → NP_722629.1  aristaless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06453, Q9VPP1
      Related
      FBpp0077713
      Conserved Domains (2) summary
      pfam00046
      Location:89 → 141
      Homeobox; Homeobox domain
      pfam03826
      Location:374 → 391
      OAR; OAR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06453.2 Q06453

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools