uif uninflatable [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: uifprovided by FlyBase
Official Full Name: uninflatableprovided by FlyBase
Primary source: FLYBASE:FBgn0031879
Locus tag: Dmel_CG9138
See related: AllianceGenome:FB:FBgn0031879
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9138; CT26172; Dmel\CG9138; poly-EGF; Poly-EGF; sp1070; SP1070; Uif
Summary: Enables Notch binding activity. Involved in several processes, including cell fate determination; muscle cell cellular homeostasis; and negative regulation of Notch signaling pathway. Located in apical plasma membrane and early endosome membrane. Is expressed in several structures, including adult head; embryonic/larval salivary gland; epithelium; gut section; and larval tracheal system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27D1-27D3; 2-24 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6972828..7010359, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6972828..7010359, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch binds Uninflatable, and both traffic together through Sara endosomes, which is essential to direct asymmetric endosomes motility and Notch-dependent cell fate assignation.
Title: Uninflatable and Notch control the targeting of Sara endosomes during asymmetric division.
Uif can modulate Notch activity
Title: Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila.
Uif is highly conserved in insect species. uif is expressed zygotically beginning in stage 5 embryos, and Uif protein localizes to the apical plasma membrane in all ectodermally derived epithelia, most notably in the tracheal system
Title: uninflatable encodes a novel ectodermal apical surface protein required for tracheal inflation in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c6998548-6991487 mobile_element_type = transposon:HMS-Beagle{}318

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tube architecture, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uninflatable

Names: CG9138-PB; CG9138-PC; CG9138-PD; CG9138-PE; CG9138-PF; CG9138-PG; SP1070; uif-PB; uif-PC; uif-PD; uif-PE; uif-PF; uif-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6972828..7010359 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135247.6 → NP_609091.4 uninflatable, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609091.4

Status: REVIEWED

UniProtKB/TrEMBL

B7Z036, Q9VM55

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001258993.2 → NP_001245922.1 uninflatable, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245922.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHA6

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001258995.2 → NP_001245924.1 uninflatable, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245924.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHA6

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001144332.3 → NP_001137804.1 uninflatable, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137804.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z036, Q9VM55

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001258994.2 → NP_001245923.1 uninflatable, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245923.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHA6

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169428.3 → NP_001162899.1 uninflatable, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162899.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHA6

Conserved Domains (14) summary

cd00033
Location:1051 → 1106

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00034
Location:36 → 167

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00179
Location:792 → 829

EGF_CA; Calcium-binding EGF-like domain

smart00231
Location:828 → 977

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

PHA02927
Location:568 → 733

PHA02927; secreted complement-binding protein; Provisional

cd00041
Location:326 → 435

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00054
Location:2059 → 2095

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:833 → 976

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00112
Location:172 → 206

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:2025 → 2055

EGF; EGF-like domain

pfam07699
Location:1862 → 1909

GCC2_GCC3; GCC2 and GCC3

pfam14670
Location:988 → 1016

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl03620
Location:2799 → 2877

DUF5011; Domain of unknown function (DUF5011)

cl22861
Location:2590 → 2735

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...