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    CG6873 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6873provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030951
    Locus tag
    Dmel_CG6873
    See related
    AllianceGenome:FB:FBgn0030951
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adf; Dmel\CG6873
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament fragmentation and actin filament severing. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6873 in Genome Data Viewer
    Location:
    17D3-17D3; 1-60 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18739216..18739895, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18633249..18633928, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45512 Neighboring gene long non-coding RNA:CR45513 Neighboring gene uncharacterized protein Neighboring gene Cholecystokinin-like receptor at 17D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SKAR is a specific target of S6 kinase 1 in cell growth control. Richardson CJ, et al. Curr Biol, 2004 Sep 7. PMID 15341740
    2. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. Deng S, et al. Dev Biol, 2021 Jan 1. PMID 32980309, Free PMC Article
    3. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    4. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    5. RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. Dorer MS, et al. PLoS Pathog, 2006 Apr. PMID 16652170, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    Adf/cofilin-like
    CG6873-PA
    cofilin homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18739216..18739895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133093.2 → NP_573321.1  uncharacterized protein Dmel_CG6873 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWR1
      Related
      FBpp0074378
      Conserved Domains (1) summary
      cd11286
      Location:3 → 142
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWR1 Q9VWR1

    Gene LinkOut

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