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    NFC5 nucleosome/chromatin assembly factor group C5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829094, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NFC5
    Official Full Name
    nucleosome/chromatin assembly factor group C5
    Primary source
    TAIR:AT4G29730
    Locus tag
    AT4G29730
    See related
    Araport:AT4G29730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MSI5; nucleosome/chromatin assembly factor group C5; T16L4.240; T16L4_240
    Summary
    cell cycle-related repressor genes encoding WD-repeat proteins.
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    Genomic context

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    See NFC5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (14558927..14562601, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Alkaline-phosphatase-like family protein Neighboring gene polyamine oxidase 5 Neighboring gene uncharacterized protein Neighboring gene cytokinin oxidase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A matrix protein silences transposons and repeats through interaction with retinoblastoma-associated proteins. Xu Y, et al. Curr Biol, 2013 Feb 18. PMID 23394836
    2. Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. Gu X, et al. PLoS Genet, 2011 Nov. PMID 22102827, Free PMC Article
    3. Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and regulate flowering time. Zhou JX, et al. J Integr Plant Biol, 2018 May. PMID 29314758
    4. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    5. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341975.1
    NM_001341976.1
    NM_119118.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome/chromatin assembly factor group C5
    NP_194702.2
    • nucleosome/chromatin assembly factor group C5 (NFC5); CONTAINS InterPro DOMAIN/s: Histone-binding protein RBBP4 (InterPro:IPR022052), WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT2G19520.1); Has 24856 Blast hits to 17343 proteins in 647 species: Archae - 12; Bacteria - 3162; Metazoa - 9403; Fungi - 5971; Plants - 3158; Viruses - 0; Other Eukaryotes - 3150 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14558927..14562601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119118.3 → NP_194702.2  nucleosome/chromatin assembly factor group C5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NQ53, Q9SU78
      UniProtKB/TrEMBL
      A0A5S9XX46, A0A654FUH5
      Conserved Domains (3) summary
      sd00039
      Location:148 → 197
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:56 → 123
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:143 → 395
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001341975.1 → NP_001329130.1  nucleosome/chromatin assembly factor group C5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6T2, A0A5S9XX46

    3. NM_001341976.1 → NP_001329131.1  nucleosome/chromatin assembly factor group C5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6T2, A0A5S9XX46
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU78.2

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