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    Vav Vav guanine nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vavprovided by FlyBase
    Official Full Name
    Vav guanine nucleotide exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040068
    Locus tag
    Dmel_CG7893
    See related
    AllianceGenome:FB:FBgn0040068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH01128; CG7893; Dmel\CG7893; DmVav; DroVav; vav
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and regulation of signal transduction. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vav in Genome Data Viewer
    Location:
    18B6-18B7; 1-62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19261820..19273280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19155853..19167313)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-B Neighboring gene rapamycin-insensitive companion of Tor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins. Barreira M, et al. Sci Signal, 2014 Apr 15. PMID 24736456
    2. Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav. Dekel I, et al. FEBS Lett, 2000 Apr 21. PMID 10781813
    3. Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family. Couceiro JR, et al. Exp Cell Res, 2005 Aug 15. PMID 15950967, Free PMC Article
    4. GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. Fernández-Espartero CH, et al. J Cell Sci, 2013 May 15. PMID 23525006
    5. Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Sarkar A, et al. Curr Biol, 2007 Jul 17. PMID 17629483

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vav independently regulates synaptic growth and plasticity through distinct actin-based processes.
      Title: Vav independently regulates synaptic growth and plasticity through distinct actin-based processes.
    2. Findings establish that Vav acts at multiple times during eye development to prevent excessive cell recruitment by limiting EGFR signalling and by regulating junction dynamics to ensure the correct patterning and morphogenesis of the Drosophila eye.
      Title: The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development.
    3. regulator of Rac activity in a developmentally regulated cell migration
      Title: GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
    4. vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity
      Title: The guanine exchange factor vav controls axon growth and guidance during Drosophila development.
    5. DroVav has a role as a signal transducer that participates in receptor tyrosine kinase pathways and functions as a GEF for the small RhoGTPase, DRac
      Title: DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Vav guanine nucleotide exchange factor
    Names
    CG7893-PA
    CG7893-PB
    CG7893-PC
    CG7893-PD
    Vav ortholog
    Vav-PA
    Vav-PB
    Vav-PC
    Vav-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19261820..19273280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167642.3 → NP_728235.1  Vav guanine nucleotide exchange factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVJ3, A4V4R6, Q8SWT3, Q8T061, Q9NHV9, Q9VWJ5
      Related
      FBpp0074449
      Conserved Domains (7) summary
      cd09940
      Location:616 → 726
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:416 → 545
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:553 → 596
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:433 → 541
      PH; PH domain
      pfam00307
      Location:20 → 132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:220 → 395
      RhoGEF; RhoGEF domain
      cl17036
      Location:732 → 785
      SH3; Src Homology 3 domain superfamily

    2. NM_001103560.3 → NP_001097030.1  Vav guanine nucleotide exchange factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUQ9
      Conserved Domains (7) summary
      cd09940
      Location:824 → 934
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:624 → 753
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:761 → 804
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:641 → 749
      PH; PH domain
      pfam00307
      Location:20 → 132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:428 → 603
      RhoGEF; RhoGEF domain
      cl17036
      Location:940 → 993
      SH3; Src Homology 3 domain superfamily

    3. NM_001272774.1 → NP_001259703.1  Vav guanine nucleotide exchange factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHJ6
      Conserved Domains (7) summary
      cd09940
      Location:787 → 897
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:587 → 716
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:724 → 767
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:604 → 712
      PH; PH domain
      pfam00307
      Location:20 → 132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:391 → 566
      RhoGEF; RhoGEF domain
      cl17036
      Location:903 → 956
      SH3; Src Homology 3 domain superfamily

    4. NM_133144.4 → NP_573372.1  Vav guanine nucleotide exchange factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVJ3, A4V4R6, Q8SWT3, Q8T061, Q9NHV9, Q9VWJ5
      Related
      FBpp0074448
      Conserved Domains (7) summary
      cd09940
      Location:616 → 726
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:416 → 545
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:553 → 596
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:433 → 541
      PH; PH domain
      pfam00307
      Location:20 → 132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:220 → 395
      RhoGEF; RhoGEF domain
      cl17036
      Location:732 → 785
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUQ9 A8JUQ9
    M9PHJ6 M9PHJ6
    Q9NHV9.2 Q9NHV9

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