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    Glos Gaulos [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31348, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Glosprovided by FlyBase
    Official Full Name
    Gaulosprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029686
    Locus tag
    Dmel_CG2941
    See related
    AllianceGenome:FB:FBgn0029686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2941; Dmel\CG2941; Gem4; Gem4a; GEMIN4
    Summary
    Part of SMN complex. Is expressed in several structures, including antennal anlage; embryonic/larval midgut primordium; germline cell; head epidermis primordium; and mesoderm. Used to study neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Glos in Genome Data Viewer
    Location:
    3F7-3F7; 1-5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3936517..3940582)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3830550..3834615)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gemin 4b Neighboring gene Gemin 4c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome. Altassan R, et al. Am J Med Genet A, 2022 Oct. PMID 35861185
    2. SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1. Cacciottolo R, et al. Sci Rep, 2019 Dec 10. PMID 31822699, Free PMC Article
    3. Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. Maccallini P, et al. PLoS Genet, 2020 May. PMID 32453722, Free PMC Article
    4. Disruption of Survival Motor Neuron in Glia Impacts Survival but has no Effect on Neuromuscular Function in Drosophila. Farrugia M, et al. Neuroscience, 2022 May 21. PMID 35314252
    5. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. Lanfranco M, et al. FEBS Lett, 2017 Nov. PMID 28949413

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 3940027-3940300 mobile_element_type = transposon:gypsy8{}1989

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of SMN complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gaulos
    Names
    CG2941-PA
    CG2941-PB
    Gemin4
    Gemin4a
    Glos-PA
    Glos-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3936517..3940582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297919.1 → NP_001284848.1  gaulos, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284848.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4N9

    2. NM_130730.2 → NP_570086.1  gaulos, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570086.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4N9
      Related
      FBpp0070586
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4N9 Q9W4N9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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