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    Vav Vav guanine nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vavprovided by FlyBase
    Official Full Name
    Vav guanine nucleotide exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040068
    Locus tag
    Dmel_CG7893
    See related
    AllianceGenome:FB:FBgn0040068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH01128; CG7893; Dmel\CG7893; DmVav; DroVav; vav
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and regulation of signal transduction. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Vav in Genome Data Viewer
    Location:
    18B6-18B7; 1-62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19261820..19273280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19155853..19167313)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-B Neighboring gene rapamycin-insensitive companion of Tor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in border follicle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Vav guanine nucleotide exchange factor
    Names
    CG7893-PA
    CG7893-PB
    CG7893-PC
    CG7893-PD
    Vav ortholog
    Vav-PA
    Vav-PB
    Vav-PC
    Vav-PD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19261820..19273280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167642.3NP_728235.1  Vav guanine nucleotide exchange factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVJ3, A4V4R6, Q8SWT3, Q8T061, Q9NHV9, Q9VWJ5
      Related
      FBpp0074449
      Conserved Domains (7) summary
      cd09940
      Location:616726
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:416545
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:553596
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:433541
      PH; PH domain
      pfam00307
      Location:20132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:220395
      RhoGEF; RhoGEF domain
      cl17036
      Location:732785
      SH3; Src Homology 3 domain superfamily
    2. NM_001103560.3NP_001097030.1  Vav guanine nucleotide exchange factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUQ9
      Conserved Domains (7) summary
      cd09940
      Location:824934
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:624753
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:761804
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:641749
      PH; PH domain
      pfam00307
      Location:20132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:428603
      RhoGEF; RhoGEF domain
      cl17036
      Location:940993
      SH3; Src Homology 3 domain superfamily
    3. NM_001272774.1NP_001259703.1  Vav guanine nucleotide exchange factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHJ6
      Conserved Domains (7) summary
      cd09940
      Location:787897
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:587716
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:724767
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:604712
      PH; PH domain
      pfam00307
      Location:20132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:391566
      RhoGEF; RhoGEF domain
      cl17036
      Location:903956
      SH3; Src Homology 3 domain superfamily
    4. NM_133144.4NP_573372.1  Vav guanine nucleotide exchange factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVJ3, A4V4R6, Q8SWT3, Q8T061, Q9NHV9, Q9VWJ5
      Related
      FBpp0074448
      Conserved Domains (7) summary
      cd09940
      Location:616726
      SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
      cd01223
      Location:416545
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:553596
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00169
      Location:433541
      PH; PH domain
      pfam00307
      Location:20132
      CH; Calponin homology (CH) domain
      pfam00621
      Location:220395
      RhoGEF; RhoGEF domain
      cl17036
      Location:732785
      SH3; Src Homology 3 domain superfamily