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    TotA Turandot A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TotAprovided by FlyBase
    Official Full Name
    Turandot Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028396
    Locus tag
    Dmel_CG31509
    See related
    AllianceGenome:FB:FBgn0028396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31509; DIM 31; Dmel\CG31509; tot; Tot; Tot A; Tot-A; totA; Turt
    Summary
    Involved in several processes, including cellular response to mechanical stimulus; response to methylmercury; and response to water deprivation. Located in extracellular space. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TotA in Genome Data Viewer
    Location:
    93A2-93A2; 3-69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20871036..20871700)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16696758..16697422)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 93a Neighboring gene mir-1011 stem loop Neighboring gene Kainate-type ionotropic glutamate receptor subunit 1D Neighboring gene Turandot C Neighboring gene Turandot B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylmercury tolerance is associated with the humoral stress factor gene Turandot A. Mahapatra CT, et al. Neurotoxicol Teratol, 2012 Jul. PMID 22546818, Free PMC Article
    2. A humoral stress response in Drosophila. Ekengren S, et al. Curr Biol, 2001 Sep 18. PMID 11566110
    3. Expression of chronic myeloid leukemia oncogenes BCR-ABL (P210) and BCR-ABL (T315I) affect cellular and humoral innate immunity in Drosophila melanogaster. Abubaker D, et al. MicroPubl Biol, 2022. PMID 35622506, Free PMC Article
    4. Parallel gene expression evolution in natural and laboratory evolved populations. Hsu SK, et al. Mol Ecol, 2021 Feb. PMID 32979867, Free PMC Article
    5. Endosymbiont-based immunity in Drosophila melanogaster against parasitic nematode infection. Yadav S, et al. PLoS One, 2018. PMID 29466376, Free PMC Article

    See all (173) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whole genome transcript profiling of developing larval brains of MeHg-tolerant and non-tolerant flies has identified Turandot A (TotA) as a potential MeHg tolerance gene.
      Title: Methylmercury tolerance is associated with the humoral stress factor gene Turandot A.
    2. The tota genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1.
      Title: The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellular response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium HEP PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methylmercury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    turandot A
    Names
    CG31509-PA
    Stress-inducible humoral factor turandot A
    TotA-PA
    Turandot-A
    turandot

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20871036..20871700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080517.3 → NP_536778.2  turandot A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536778.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IN44, Q95NS3
      UniProtKB/TrEMBL
      A0A1B2AIV9
      Related
      FBpp0083378
      Conserved Domains (1) summary
      pfam07240
      Location:41 → 117
      Turandot; Stress-inducible humoral factor Turandot
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IN44.1 Q8IN44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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