U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tdc2 Tyrosine decarboxylase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246620, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tdc2provided by FlyBase
    Official Full Name
    Tyrosine decarboxylase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0050446
    Locus tag
    Dmel_CG30446
    See related
    AllianceGenome:FB:FBgn0050446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30446; CG3686; Dmel\CG30446; dTdc2; tdc; Tdc; TDC; tdc2; TdC2; TDC2
    Summary
    Predicted to enable tyrosine decarboxylase activity. Involved in behavioral response to cocaine; egg-laying behavior; and locomotor rhythm. Predicted to be active in cytoplasm. Is expressed in several structures, including adult abdominal segment 6; ganglia; neuromere; neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tdc2 in Genome Data Viewer
    Location:
    42C4-42C4; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6684745..6689974, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2572250..2577479, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene long non-coding RNA:CR44164 Neighboring gene antisense RNA:CR44165 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene Rab2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A comprehensive anatomical map of the peripheral octopaminergic/tyraminergic system of Drosophila melanogaster. Pauls D, et al. Sci Rep, 2018 Oct 17. PMID 30333565, Free PMC Article
    2. Gut microbiome modulates Drosophila aggression through octopamine signaling. Jia Y, et al. Nat Commun, 2021 May 11. PMID 33976215, Free PMC Article
    3. A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii. Ma S, et al. PLoS Genet, 2024 Apr. PMID 38578788, Free PMC Article
    4. Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila. Cheng KY, et al. Curr Biol, 2019 Jun 17. PMID 31155354, Free PMC Article
    5. Dopaminergic neurons mediate male Drosophila courtship motivational state. Wang G. Biochem Biophys Res Commun, 2022 Jun 25. PMID 35430448

    See all (159) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dTdc1 and dTdc2 are functional but noncomplementing Drosophila tyrosine decarboxylase genes: dTdc1 is expressed nonneurally, whereas dTdc2 is expressed neurally
      Title: Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine decarboxylase 2
    Names
    CG30446-PA
    Tdc2-PA
    tyrosine decarboxylase
    NP_724489.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6684745..6689974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165483.3 → NP_724489.1  tyrosine decarboxylase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6N4
      Related
      FBpp0085475
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6N4 A1Z6N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools