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    TwdlM TweedleM [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlMprovided by FlyBase
    Official Full Name
    TweedleMprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039434
    Locus tag
    Dmel_CG5468
    See related
    AllianceGenome:FB:FBgn0039434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5468; Dmel\CG5468; twdlM; TWDLM
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlM in Genome Data Viewer
    Location:
    97C2-97C2; 3-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26619118..26620224)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22444840..22445946)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44951 Neighboring gene long non-coding RNA:CR45788 Neighboring gene TweedleP Neighboring gene TweedleB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABC transporter Snu and the extracellular protein Snsl cooperate in the formation of the lipid-based inward and outward barrier in the skin of Drosophila. Zuber R, et al. Eur J Cell Biol, 2018 Mar. PMID 29306642
    2. Inhibition of fatty acid desaturation impairs cuticle differentiation in Drosophila melanogaster. Wang Y, et al. Arch Insect Biochem Physiol, 2019 Apr. PMID 30672604
    3. The putative C-type lectin Schlaff ensures epidermal barrier compactness in Drosophila. Zuber R, et al. Sci Rep, 2019 Mar 29. PMID 30926832, Free PMC Article
    4. A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms. Kaufman JD, et al. Sci Rep, 2021 Mar 19. PMID 33742039, Free PMC Article
    5. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleM
    Names
    CG5468-PA
    TwdlM-PA
    tweedle
    tweedle M

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26619118..26620224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143227.2 → NP_651484.1  TweedleM [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651484.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBE2
      Related
      FBpp0084401
      Conserved Domains (1) summary
      smart00690
      Location:126 → 227
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBE2 Q9VBE2

    Gene LinkOut

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