rl rolled [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rlprovided by FlyBase
Official Full Name: rolledprovided by FlyBase
Primary source: FLYBASE:FBgn0003256
Locus tag: Dmel_CG12559
See related: AllianceGenome:FB:FBgn0003256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 12559; BcDNA:RE08694; CG12559; CG18732; CT34260; CT39192; D-ERK; dErk; dERK; DERK; DERK-A; dm-dpERK; Dmel\CG12559; DmErk; DmERK; DmERK-A; DmERKA; DmMAPK; dp-ERK; dpErk; dpERk; dpERK; DpErk; DpERK; dpERK1; dpMAPK; Dsor2; E(sina)7; EC2-1; EK2-1; erk; Erk; ERK; ERK-A; Erk/Map kinase; Erk1; ERK1; Erk1/2; ERK1/2; ErkA; ERKa; ERKA; EY2-2; GroupII; l(2)41Ac; l(2R)EMS45-39; MAP-k; mapk; Mapk; MapK; MAPK; p-Erk; p-ERK; pERK; pMapK; pMAPK; Rl; RL; rl/ERK; rl/MAPK; rll; Rolled; sem; Sem; SEM; SR2-1; Su(Raf)2B
Summary: Enables DNA-binding transcription factor binding activity; MAP kinase activity; and protein kinase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; larval lymph gland hemocyte differentiation; and regionalization. Located in cytosol; neuromuscular junction; and nucleus. Is expressed in several structures, including imaginal disc; mesoderm; somatic precursor cell; visceral mesoderm derivative; and wing vein. Used to study cancer and chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in Noonan syndrome 13; Parkinson's disease; carcinoma (multiple); melanoma; and pulmonary hypertension. Orthologous to several human genes including MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 41A1-41A1; 2-55 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (1071462..1125927)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2RHet	NW_001848856.1 (198176..252641)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisomal ERK mediates Akh/glucagon action and glycemic control.
Title: Peroxisomal ERK mediates Akh/glucagon action and glycemic control.
the common docking site is in an energetically strained configuration, and this helps drive conformational changes at distal sites on ERK2 during docking interactions.
Title: Functional divergence caused by mutations in an energetic hotspot in ERK2.
Results suggest that Rolled/ERK-MAPK activation in somatic cyst cells downstream of EGFR is essential for synchronizing the germ-cell divisions within a cyst at every step during the transit amplification.
Title: Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions in Drosophila testis.
In the presence of USP47, MAPK would be stabilized as USP47 acts to deubiquitinate MAPK, thus counteracting the direct ubiquitination of MAPK by POE/UBR4 activity.
Title: The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells, leading to the expression of Dilp8.
Title: The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
Holn1 acts downstream of EGFR and ERK signaling in the Grh/Fos mediated wound closure pathway.
Title: Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes
Title: The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
These results identify a role for the Exon Junction Complex (EJC) in the splicing of a subset of transcripts and suggest that RAS/MAPK signaling depends on the regulation of MAPK levels by the EJC.
Title: The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.
MAPK is the primary functional target of mago in eye development; in cultured cells, Mago knockdown disproportionately affects other large genes located in heterochromatin
Title: Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene.
Data show that Fak56 suppresses MAPK activation in neuromuscular junction growth.
Title: Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 1094716-1095802 mobile_element_type = transposon:1360{}6323

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	HGI more info	PubMed
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in leg disc proximal/distal pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sevenless signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in torso signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tracheal pit formation in open tracheal system	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rolled

Names: CG12559-PA; CG12559-PC; CG12559-PD; CG12559-PE; CG12559-PG; CG12559-PH; CG12559-PI; Diphospho-ERK; ERK; ERK/rolled; Erk MAP kinase; Extracellular-regulated kinase A; Extracellular-signal-related kinase A; MAP kinase; MAP-kinase; MAPK; dp-ERK; dpERK; drosophila ERK; enhancer of seven in absentia 7; extracellular signal-regulated kinase; extracellular signal-regulated kinase A; mitogen activated protein kinase; mitogen-activated protein kinase; phospho-ERK; rl-PA; rl-PC; rl-PD; rl-PE; rl-PG; rl-PH; rl-PI; roll; sevenmaker

NP_001015121.3

EC 2.7.11.1

EC 2.7.11.24

NP_001015122.1

EC 2.7.11.1

EC 2.7.11.24

NP_001015123.1

EC 2.7.11.1

EC 2.7.11.24

NP_001104348.2

EC 2.7.11.1

EC 2.7.11.24

NP_001104349.1

EC 2.7.11.1

EC 2.7.11.24

NP_001104350.1

EC 2.7.11.1

EC 2.7.11.24

NP_001287635.1

EC 2.7.11.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

1071462..1125927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001015122.3 → NP_001015122.1 rolled, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015122.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A021WW06, A8Y4W1, A8Y4W2, P40417, Q7PL59, Q9W5M2, Q9W5M3

UniProtKB/TrEMBL

M9ZYW3

Conserved Domains (2) summary

smart00220
Location:38 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:32 → 366

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001110878.4 → NP_001104348.2 rolled, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104348.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P40417

Conserved Domains (2) summary

smart00220
Location:3 → 216

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:1 → 256

PKc_like; Protein Kinases, catalytic domain
NM_001300706.2 → NP_001287635.1 rolled, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A021WW06, A8Y4W1, A8Y4W2, P40417, Q7PL59, Q9W5M2, Q9W5M3

UniProtKB/TrEMBL

M9ZYW3

Conserved Domains (2) summary

smart00220
Location:38 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:32 → 366

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001015121.3 → NP_001015121.3 rolled, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015121.3

Status: REVIEWED

UniProtKB/TrEMBL

M9ZYW3

Conserved Domains (2) summary

smart00220
Location:12 → 281

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:6 → 321

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001015123.3 → NP_001015123.1 rolled, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001015123.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A021WW06, A8Y4W1, A8Y4W2, P40417, Q7PL59, Q9W5M2, Q9W5M3

UniProtKB/TrEMBL

M9ZYW3

Conserved Domains (2) summary

smart00220
Location:38 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:32 → 366

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001110879.2 → NP_001104349.1 rolled, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104349.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A021WW06, A8Y4W1, A8Y4W2, P40417, Q7PL59, Q9W5M2, Q9W5M3

UniProtKB/TrEMBL

M9ZYW3

Conserved Domains (2) summary

smart00220
Location:38 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:32 → 366

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_001110880.2 → NP_001104350.1 rolled, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001104350.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y4W5

Conserved Domains (1) summary

cl21453
Location:32 → 134

PKc_like; Protein Kinases, catalytic domain