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    Pld3 Phospholipase D family member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pld3provided by FlyBase
    Official Full Name
    Phospholipase D family member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032923
    Locus tag
    Dmel_CG9248
    See related
    AllianceGenome:FB:FBgn0032923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9248; Dmel\CG9248; dPLD3
    Summary
    Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in endoplasmic reticulum membrane and lysosomal lumen. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pld3 in Genome Data Viewer
    Location:
    39A6-39A7; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21158847..21160903)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21158847..21160903)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 2 Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function. Demirev AV, et al. Neurobiol Dis, 2019 Sep. PMID 31121321
    2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
    3. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Hansen KD, et al. PLoS Genet, 2009 Jun. PMID 19543372, Free PMC Article
    4. Genetic Dissection of Alzheimer's Disease Using Drosophila Models. Jeon Y, et al. Int J Mol Sci, 2020 Jan 30. PMID 32019113, Free PMC Article
    5. Transcriptional response to alcohol exposure in Drosophila melanogaster. Morozova TV, et al. Genome Biol, 2006. PMID 17054780, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase D family member 3
    Names
    CG9248-PA
    CG9248-PB
    CG9248-PC
    Pld3-PA
    Pld3-PB
    Pld3-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21158847..21160903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136249.2 → NP_610093.1  phospholipase D family member 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIF2
      Related
      FBpp0080999
      Conserved Domains (3) summary
      PHA03003
      Location:84 → 493
      PHA03003; palmytilated EEV membrane glycoprotein; Provisional
      cd09106
      Location:89 → 249
      PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
      cd09107
      Location:316 → 486
      PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

    2. NM_001299188.1 → NP_001286117.1  phospholipase D family member 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIF2
      Conserved Domains (3) summary
      PHA03003
      Location:84 → 493
      PHA03003; palmytilated EEV membrane glycoprotein; Provisional
      cd09106
      Location:89 → 249
      PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
      cd09107
      Location:316 → 486
      PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

    3. NM_165356.3 → NP_724313.1  phospholipase D family member 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIF2
      Related
      FBpp0081000
      Conserved Domains (3) summary
      PHA03003
      Location:84 → 493
      PHA03003; palmytilated EEV membrane glycoprotein; Provisional
      cd09106
      Location:89 → 249
      PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
      cd09107
      Location:316 → 486
      PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIF2 Q9VIF2

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