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    NHP2 NHP2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44005, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NHP2provided by FlyBase
    Official Full Name
    NHP2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029148
    Locus tag
    Dmel_CG5258
    See related
    AllianceGenome:FB:FBgn0029148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5258; Dmel\CG5258; nhp2
    Summary
    Predicted to enable box H/ACA snoRNA binding activity. Involved in germarium-derived cystoblast division. Located in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NHP2 in Genome Data Viewer
    Location:
    70F6-70F6; 3-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14801328..14802168, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14794428..14795268, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tudor domain containing 3 Neighboring gene Helicase with zinc finger Neighboring gene uncharacterized protein Neighboring gene giant nuclei

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of NHP2 promotes proper cyst formation in Drosophila ovary. Morita S, et al. Dev Growth Differ, 2018 Jun. PMID 29845608
    2. giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Renault AD, et al. Development, 2003 Jul. PMID 12756181
    3. Selenoprotein dSelK in Drosophila elevates release of Ca2+ from endoplasmic reticulum by upregulating expression of inositol 1,4,5-tris-phosphate receptor. Ben SB, et al. Biochemistry (Mosc), 2011 Sep. PMID 22082272
    4. An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes. Estrada B, et al. PLoS Genet, 2006 Feb. PMID 16482229, Free PMC Article
    5. Native purification of protein and RNA-protein complexes using a novel affinity procedure. Kroiss M, et al. Fly (Austin), 2009 Jul-Sep. PMID 19690462

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA pseudouridine synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NHP2
    Names
    CG5258-PA
    CG5258-PB
    NHP2-PA
    NHP2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14801328..14802168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274920.1 → NP_001261849.1  NHP2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q494M4, Q9V3U2
      UniProtKB/TrEMBL
      M9PCI2
      Conserved Domains (1) summary
      pfam01248
      Location:51 → 146
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    2. NM_143708.3 → NP_651965.1  NHP2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q494M4, Q9V3U2
      UniProtKB/TrEMBL
      M9PCI2
      Related
      FBpp0075448
      Conserved Domains (1) summary
      pfam01248
      Location:51 → 146
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCI2 M9PCI2
    Q9V3U2.1 Q9V3U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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