Gmer GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gmerprovided by FlyBase
Official Full Name: GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductaseprovided by FlyBase
Primary source: FLYBASE:FBgn0267823
Locus tag: Dmel_CG3495
See related: AllianceGenome:FB:FBgn0267823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3495; Dmel\CG3495; DmGMER; GER; gmer; l(2)SH1931
Summary: Enables GDP-L-fucose synthase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process and dsRNA transport. Predicted to be located in cytosol. Is expressed in organism. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 59B4-59B4; 2-101 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22887574..22888857, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18775097..18776380, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning, purification and charactrization of Gmer
Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GDP-L-fucose synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-L-fucose synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP-mannose 3,5-epimerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-sugar biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase

Names: CG3495-PA; GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase; Gmer-PA; lethal (2) SH1931

NP_611734.1

EC 1.-.-.-

EC 1.1.1.271

EC 5.1.3.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22887574..22888857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137890.3 → NP_611734.1 GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1H8X1, Q8MS16, Q9W1X8

UniProtKB/TrEMBL

B6IDX2

Related

FBpp0071816

Conserved Domains (2) summary

cd05239
Location:3 → 313

GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

pfam01370
Location:4 → 234

Epimerase; NAD dependent epimerase/dehydratase family