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    nAChRalpha1 nicotinic Acetylcholine Receptor alpha1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nAChRalpha1provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000036
    Locus tag
    Dmel_CG5610
    See related
    AllianceGenome:FB:FBgn0000036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AChr; AChR; AChRalpha1; Acr96A; Acr96Aa; AcrB; alpha-like; alpha1; als; ALs; ALS; CG5610; CG5610-PA; Dalpha1; Dalpha1 nAChR; dALS; Dmel\CG5610; EMS1; nAChR; nAChR-alpha96Aa; nAChRa1; nAChRalpha-96Aa; nAChRDalpha1; nAcr96Aa; NAcRa96Aa; nAcRalpha-96Aa; nAcRs
    Summary
    Contributes to acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in cholinergic synaptic transmission; monoatomic cation transmembrane transport; and response to insecticide. Part of acetylcholine-gated channel complex. Is expressed in several structures, including adult head; adult mushroom body; adult optic lobe columnar neurons; brain; and larval central nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nAChRalpha1 in Genome Data Viewer
    Location:
    96A1-96A2; 3-85 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24393896..24457157, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20219618..20282879, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43455 Neighboring gene long non-coding RNA:CR45950 Neighboring gene long non-coding RNA:CR45649 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combined effects of mutations in loop C and the loop D-E-G triangle on neonicotinoid interactions with Drosophila Dα1/chicken β2 hybrid nAChRs. Hikida M, et al. Pestic Biochem Physiol, 2018 Oct. PMID 30704712
    2. Patterns of transposable element variation and clinality in Drosophila. Adrion JR, et al. Mol Ecol, 2019 Mar. PMID 30484926, Free PMC Article
    3. Deletion of the nicotinic acetylcholine receptor subunit gene Dα1 confers insecticide resistance, but at what cost? Somers J, et al. Fly (Austin), 2018 Jan 2. PMID 29095106, Free PMC Article
    4. The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests. Shimada S, et al. Sci Rep, 2020 May 5. PMID 32371996, Free PMC Article
    5. Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor. Ihara M, et al. Br J Pharmacol, 2018 Jun. PMID 28616862, Free PMC Article

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila.
      Title: Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila.
    2. Study demonstrated several roles of the Dalpha1 nAChR subunit it is the target of the neonicotinoid class of insecticides and also uncovered roles for the gene in influencing mating behavior, patterns of sleep and life span.
      Title: Deletion of the nicotinic acetylcholine receptor subunit gene Dα1 confers insecticide resistance, but at what cost?
    3. mutation can confer nitenpyram resistance
      Title: Mutations in Dalpha1 or Dbeta2 nicotinic acetylcholine receptor subunits can confer resistance to neonicotinoids in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insecticide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha1
    Names
    ALS
    CG5610-PA
    CG5610-PB
    CG5610-PC
    Dalpha1
    alpha-like subunit
    alpha-like-subunit
    nAChRalpha1-PA
    nAChRalpha1-PB
    nAChRalpha1-PC
    nicotinic acetylcholine receptor alpha 96Aa
    nicotinic acetylcholine receptor alpha-96Aa
    nicotinic acetylcholine receptor alpha-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24393896..24457157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275988.2 → NP_001262917.1  nicotinic acetylcholine receptor alpha1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09478, Q9VC74
      UniProtKB/TrEMBL
      A0A0B4KHE6
      Conserved Domains (3) summary
      TIGR00860
      Location:27 → 530
      LIC; Cation transporter family protein
      pfam02931
      Location:25 → 240
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 530
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_079757.4 → NP_524481.2  nicotinic acetylcholine receptor alpha1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524481.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09478, Q9VC74
      UniProtKB/TrEMBL
      A0A0B4KHE6
      Related
      FBpp0084003
      Conserved Domains (3) summary
      TIGR00860
      Location:27 → 530
      LIC; Cation transporter family protein
      pfam02931
      Location:25 → 240
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 530
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001275987.1 → NP_001262916.1  nicotinic acetylcholine receptor alpha1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGU3
      Conserved Domains (3) summary
      TIGR00860
      Location:27 → 530
      LIC; Cation transporter family protein
      pfam02931
      Location:25 → 240
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 530
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGU3 A0A0B4KGU3
    A0A0B4KHE6 A0A0B4KHE6
    P09478.2 P09478

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