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    Son Son RNA binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sonprovided by FlyBase
    Official Full Name
    Son RNA binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037716
    Locus tag
    Dmel_CG8273
    See related
    AllianceGenome:FB:FBgn0037716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8273; CG8273; Dmel\CG8273; dsn; dSon
    Summary
    Predicted to enable double-stranded RNA binding activity. Involved in several processes, including female germ-line stem cell population maintenance; negative regulation of macromolecule metabolic process; and pre-mRNA catabolic process. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in ZTTK syndrome and congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to human SON (SON DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Son in Genome Data Viewer
    Location:
    85D25-85D26; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9578042..9581225)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5403764..5406947)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene karyopherin alpha3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene P58IPK Neighboring gene bocksbeutel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline Stem Cell Heterogeneity Supports Homeostasis in Drosophila. Ng AYE, et al. Stem Cell Reports, 2018 Jul 10. PMID 29887366, Free PMC Article
    2. Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, et al. Front Physiol, 2023. PMID 37324401, Free PMC Article
    3. SON protects nascent transcripts from unproductive degradation by counteracting DIP1. Tay ML, et al. PLoS Genet, 2019 Nov. PMID 31730657, Free PMC Article
    4. Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles. Lacroix E, et al. Front Mol Biosci, 2022. PMID 36203874, Free PMC Article
    5. Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Okamura K, et al. Nat Struct Mol Biol, 2008 Jun. PMID 18500351, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-mRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Son RNA binding protein
    Names
    CG8273-PA
    CG8273-PB
    Son DNA binding protein
    Son-PA
    Son-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9578042..9581225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141657.4 → NP_649914.1  Son RNA binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IHA8, Q8MSG7, Q9VHB0
      Related
      FBpp0081550
      Conserved Domains (3) summary
      PHA03247
      Location:455 → 627
      PHA03247; large tegument protein UL36; Provisional
      cd19870
      Location:798 → 872
      DSRM_SON-like; double-stranded RNA binding motif of protein SON and similar proteins
      pfam01585
      Location:705 → 747
      G-patch; G-patch domain

    2. NM_001275497.1 → NP_001262426.1  Son RNA binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IHA8, Q8MSG7, Q9VHB0
      Conserved Domains (3) summary
      PHA03247
      Location:455 → 627
      PHA03247; large tegument protein UL36; Provisional
      cd19870
      Location:798 → 872
      DSRM_SON-like; double-stranded RNA binding motif of protein SON and similar proteins
      pfam01585
      Location:705 → 747
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHB0.1 Q9VHB0

    Gene LinkOut

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