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    E(spl)m3-HLH Enhancer of split m3, helix-loop-helix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43156, updated on 17-Dec-2024

    Summary

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    Official Symbol
    E(spl)m3-HLHprovided by FlyBase
    Official Full Name
    Enhancer of split m3, helix-loop-helixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002609
    Locus tag
    Dmel_CG8346
    See related
    AllianceGenome:FB:FBgn0002609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHc14; CG8346; Dmel\CG8346; E(spl)-C; E(Spl)-HLH-m3; E(spl)-m3; E(spl)C; E(spl)C m3; E(spl)m3; E(spl)M3; HLH-m3; HLHm3; HLHM3; m3
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of neuroblast proliferation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; germ layer; gut section; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2) and HES4 (hes family bHLH transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)m3-HLH in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26021823..26023127)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21847545..21848849)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43643 Neighboring gene long non-coding RNA:CR43644 Neighboring gene Enhancer of split m4, Bearded family member Neighboring gene Enhancer of split m5, helix-loop-helix

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Marker-based estimation of genetic parameters in genomics. Hu Z, et al. PLoS One, 2014. PMID 25025305, Free PMC Article
    2. The Notch amino terminus regulates protein levels and Delta-induced clustering of Drosophila Notch receptors. Bardot B, et al. Exp Cell Res, 2005 Mar 10. PMID 15707586
    3. Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Knust E, et al. Genetics, 1992 Oct. PMID 1427040, Free PMC Article
    4. The adhesion force of Notch with Delta and the rate of Notch signaling. Ahimou F, et al. J Cell Biol, 2004 Dec 20. PMID 15611340, Free PMC Article
    5. Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Leonardi J, et al. Development, 2011 Aug. PMID 21771811, Free PMC Article

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split m3, helix-loop-helix
    Names
    CG8346-PA
    E(spl) region transcript m3
    E(spl)m3-HLH-PA
    enhancer of split m3
    split locus enhancer protein m3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26021823..26023127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079785.4 → NP_524509.2  enhancer of split m3, helix-loop-helix [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524509.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01068, Q5S455, Q5S479, Q5S4J9
      Related
      FBpp0084332
      Conserved Domains (2) summary
      smart00511
      Location:96 → 136
      ORANGE; Orange domain
      cd00083
      Location:11 → 70
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01068.1 Q01068
    Q56LA3 Q56LA3
    Q56LC9 Q56LC9
    Q56LE8 Q56LE8
    Q56LI3 Q56LI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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