Gycalpha99B Guanylyl cyclase alpha-subunit at 99B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gycalpha99Bprovided by FlyBase
Official Full Name: Guanylyl cyclase alpha-subunit at 99Bprovided by FlyBase
Primary source: FLYBASE:FBgn0013972
Locus tag: Dmel_CG1912
See related: AllianceGenome:FB:FBgn0013972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1912; dgc1; Dgc1; dgca1; dgcalpha1; Dgcalpha1; Dmel\CG1912; Gcalpha1; GCalpha1; GYCa 99B; gycalpha; Gycalpha-99B; Gycalpha63A; sGC; sGC-alpha; SGCalpha; sGCalpha1; sGCalpha99B
Summary: Enables guanylate cyclase activity. Involved in G protein-coupled opsin signaling pathway and positive phototaxis. Part of guanylate cyclase complex, soluble. Is expressed in several structures, including adult brain; adult head; adult optic lobe; adult ventral nerve cord; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to several human genes including GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29682503..29685758)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25508225..25511480)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opsin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
part_of guanylate cyclase complex, soluble	IDA Inferred from Direct Assay more info	PubMed

Names: CG1912-PA; Gycalpha99B-PA; guanyl cyclase alpha-subunit at 63A; guanylate cyclase 99B; soluble guanylate cyclase; soluble guanylyl cyclase alpha

NP_477088.2

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The following sections contain reference sequences that belong to a specific genome build. Explain