trol terribly reduced optic lobes [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trolprovided by FlyBase
Official Full Name: terribly reduced optic lobesprovided by FlyBase
Primary source: FLYBASE:FBgn0284408
Locus tag: Dmel_CG33950
See related: AllianceGenome:FB:FBgn0284408
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1
Summary: Involved in several processes, including axon development; maintenance of epithelial cell apical/basal polarity; and regulation of signal transduction. Located in basement membrane. Is expressed in several structures, including brain; embryonic/larval lymph gland; gut section; lineage NB3-1 primary motor neurons; and neuron projection bundle. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3A3-3A4; 1-1 cM

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2470460..2545427, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2364493..2439443, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development.
Title: Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development.
Two different sources of Perlecan cooperate for its function in the basement membrane of the Drosophila wing imaginal disc.
Title: Two different sources of Perlecan cooperate for its function in the basement membrane of the Drosophila wing imaginal disc.
present evidence that the effect of Trol on blood cell differentiation is mediated by Hedgehog (Hh) signaling, which is known to be required to maintain an immature medullary zone
Title: The proteoglycan Trol controls the architecture of the extracellular matrix and balances proliferation and differentiation of blood progenitors in the Drosophila lymph gland.
perlecan is required for Sema-1a-PlexA-mediated repulsive guidance, revealing roles for extracellular matrix proteoglycans in modulating transmembrane guidance cue signaling during neural development
Title: The extracellular matrix proteoglycan perlecan facilitates transmembrane semaphorin-mediated repulsive guidance.
Trol function is not dedicated to a single molecular mechanism, but is capable of regulating different growth factor pathways depending on the cell-type and event underway
Title: The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts.
The results suggest that trol acts in the extracellular matrix and binds, stores, and sequesters external signals and, thereby, participates in the stage- and region-specific control of neuroblast proliferation.
Title: Perlecan participates in proliferation activation of quiescent Drosophila neuroblasts.
The intrinsic control over myogenic programs can only be overridden by FGF4 signals provided by the apical ectodermal ridge of a developing limb.
Title: Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors.
Trol can mediate signaling through both of the FGF and Hedgehog pathways to control the onset of stem cell proliferation in the developing nervous system.
Title: Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.
The interaction of perlecan and dystroglycan at the basal side of the epithelium promotes basal membrane differentiation and is required for maintenance of cell polarity in the follicle-cell epithelium.
Title: Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2142 (e-PCR)
- UniSTS:2621

Dm0661 (e-PCR)
- UniSTS:19350

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in defasciculation of motor neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: terribly reduced optic lobes

Names: CG33950-PAF; CG33950-PAG; CG33950-PAH; CG33950-PAI; CG33950-PAK; CG33950-PAL; CG33950-PAM; CG33950-PAN; CG33950-PAO; CG33950-PAP; CG33950-PAQ; CG33950-PAR; CG33950-PAS; CG33950-PAT; CG33950-PAU; CG33950-PAV; CG33950-PAW; CG33950-PAX; CG33950-PAY; CG33950-PAZ; CG33950-PBA; CG33950-PBB; CG33950-PBC; CG33950-PBD; CG33950-PBE; Trol/perlecan; dPerlecan; lethal (1) G0019; lethal (1) G0021; lethal (1) G0023; lethal (1) G0181; lethal (1) G0211; lethal (1) G0271; lethal (1) G0374; lethal (1) G0412; mRNA-like ncRNA in embryogenesis 7; perlecan; trol-PAF; trol-PAG; trol-PAH; trol-PAI; trol-PAK; trol-PAL; trol-PAM; trol-PAN; trol-PAO; trol-PAP; trol-PAQ; trol-PAR; trol-PAS; trol-PAT; trol-PAU; trol-PAV; trol-PAW; trol-PAX; trol-PAY; trol-PAZ; trol-PBA; trol-PBB; trol-PBC; trol-PBD; trol-PBE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2470460..2545427 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258565.3 → NP_001245494.2 terribly reduced optic lobes, isoform AY [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245494.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NFR6

Conserved Domains (15) summary

cd05743
Location:956 → 1031

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2553 → 2615

IGc2; Immunoglobulin C-2 Type

smart00409
Location:726 → 803

IG; Immunoglobulin

smart00410
Location:2456 → 2534

IG_like; Immunoglobulin like

cd00054
Location:3598 → 3630

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1666 → 1715

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3138 → 3283

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:861 → 895

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2537 → 2625

I-set; Immunoglobulin I-set domain

pfam00008
Location:3306 → 3338

EGF; EGF-like domain

pfam00052
Location:1495 → 1620

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1751 → 1781

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3669 → 3798

Laminin_G_2; Laminin G domain

pfam13895
Location:2071 → 2153

Ig_2; Immunoglobulin domain

cl11960
Location:2468 → 2535

Ig; Immunoglobulin domain
NM_001297894.2 → NP_001284823.1 terribly reduced optic lobes, isoform AV [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284823.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPN3, X2JE09

Conserved Domains (15) summary

cd05743
Location:1034 → 1109

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2693 → 2755

IGc2; Immunoglobulin C-2 Type

smart00409
Location:804 → 881

IG; Immunoglobulin

smart00410
Location:2596 → 2674

IG_like; Immunoglobulin like

cd00054
Location:3738 → 3770

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1744 → 1793

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3278 → 3423

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:939 → 973

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2677 → 2765

I-set; Immunoglobulin I-set domain

pfam00008
Location:3446 → 3478

EGF; EGF-like domain

pfam00052
Location:1573 → 1698

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1829 → 1859

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3809 → 3938

Laminin_G_2; Laminin G domain

pfam13895
Location:2211 → 2293

Ig_2; Immunoglobulin domain

cl11960
Location:2608 → 2675

Ig; Immunoglobulin domain
NM_001103399.4 → NP_001096869.3 terribly reduced optic lobes, isoform AZ [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096869.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A023GRW4, Q8MPN3

Conserved Domains (12) summary

cd05743
Location:1112 → 1187

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00410
Location:2909 → 2985

IG_like; Immunoglobulin like

cd00054
Location:3462 → 3495

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1822 → 1871

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3294 → 3439

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1017 → 1051

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00053
Location:1907 → 1937

Laminin_EGF; Laminin EGF domain

pfam07679
Location:2617 → 2690

I-set; Immunoglobulin I-set domain

cd00096
Location:2622 → 2626

Ig; Ig strand B [structural motif]

pfam00052
Location:1651 → 1787

Laminin_B; Laminin B (Domain IV)

pfam13927
Location:2514 → 2585

Ig_3; Immunoglobulin domain

cl11960
Location:2693 → 2781

Ig; Immunoglobulin domain
NM_001297893.2 → NP_001284822.1 terribly reduced optic lobes, isoform AS [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284822.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JDK9

Conserved Domains (12) summary

cd05743
Location:928 → 1003

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00410
Location:2725 → 2801

IG_like; Immunoglobulin like

cd00054
Location:3278 → 3311

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1638 → 1687

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3110 → 3255

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:833 → 867

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00053
Location:1723 → 1753

Laminin_EGF; Laminin EGF domain

pfam07679
Location:2433 → 2506

I-set; Immunoglobulin I-set domain

cd00096
Location:2438 → 2442

Ig; Ig strand B [structural motif]

pfam00052
Location:1467 → 1603

Laminin_B; Laminin B (Domain IV)

pfam13927
Location:2330 → 2401

Ig_3; Immunoglobulin domain

cl11960
Location:2509 → 2597

Ig; Immunoglobulin domain
NM_001031864.4 → NP_001027035.3 terribly reduced optic lobes, isoform AO [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027035.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRV8

Conserved Domains (15) summary

cd05743
Location:1010 → 1085

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2607 → 2669

IGc2; Immunoglobulin C-2 Type

smart00409
Location:780 → 857

IG; Immunoglobulin

smart00410
Location:2510 → 2588

IG_like; Immunoglobulin like

cd00054
Location:3652 → 3684

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1720 → 1769

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3192 → 3337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:915 → 949

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2591 → 2679

I-set; Immunoglobulin I-set domain

pfam00008
Location:3360 → 3392

EGF; EGF-like domain

pfam00052
Location:1549 → 1674

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1805 → 1835

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3723 → 3852

Laminin_G_2; Laminin G domain

pfam13895
Location:2125 → 2207

Ig_2; Immunoglobulin domain

cl11960
Location:2522 → 2589

Ig; Immunoglobulin domain
NM_001297896.2 → NP_001284825.1 terribly reduced optic lobes, isoform BA [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284825.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPN3, X2JCE8

Conserved Domains (15) summary

cd05743
Location:1326 → 1401

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2923 → 2985

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1096 → 1173

IG; Immunoglobulin

smart00410
Location:2826 → 2904

IG_like; Immunoglobulin like

cd00054
Location:3968 → 4000

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2036 → 2085

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3508 → 3653

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1231 → 1265

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2907 → 2995

I-set; Immunoglobulin I-set domain

pfam00008
Location:3676 → 3708

EGF; EGF-like domain

pfam00052
Location:1865 → 1990

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2121 → 2151

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4039 → 4168

Laminin_G_2; Laminin G domain

pfam13895
Location:2441 → 2523

Ig_2; Immunoglobulin domain

cl11960
Location:2838 → 2905

Ig; Immunoglobulin domain
NM_001258570.3 → NP_001245499.2 terribly reduced optic lobes, isoform AQ [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245499.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NFS1, Q8MPN3

Conserved Domains (14) summary

cd05743
Location:1422 → 1497

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:3019 → 3081

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1192 → 1269

IG; Immunoglobulin

smart00410
Location:2922 → 3000

IG_like; Immunoglobulin like

cd00055
Location:2132 → 2181

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3604 → 3749

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1327 → 1361

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:3003 → 3091

I-set; Immunoglobulin I-set domain

pfam00008
Location:3772 → 3804

EGF; EGF-like domain

pfam00052
Location:1961 → 2086

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2217 → 2247

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4135 → 4264

Laminin_G_2; Laminin G domain

pfam13895
Location:2537 → 2619

Ig_2; Immunoglobulin domain

cl11960
Location:2934 → 3001

Ig; Immunoglobulin domain
NM_001258564.3 → NP_001245493.2 terribly reduced optic lobes, isoform AF [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245493.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NDL5, Q8MPN3

Conserved Domains (14) summary

cd05743
Location:1495 → 1570

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:3154 → 3216

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1265 → 1342

IG; Immunoglobulin

smart00410
Location:3057 → 3135

IG_like; Immunoglobulin like

cd00055
Location:2205 → 2254

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3739 → 3884

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1400 → 1434

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:3138 → 3226

I-set; Immunoglobulin I-set domain

pfam00008
Location:3907 → 3939

EGF; EGF-like domain

pfam00052
Location:2034 → 2159

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2290 → 2320

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4270 → 4399

Laminin_G_2; Laminin G domain

pfam13895
Location:2672 → 2754

Ig_2; Immunoglobulin domain

cl11960
Location:3069 → 3136

Ig; Immunoglobulin domain
NM_001031862.4 → NP_001027033.3 terribly reduced optic lobes, isoform AW [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027033.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JUV8, Q8IRV9, Q8MPN3

Conserved Domains (15) summary

cd05743
Location:1130 → 1205

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2727 → 2789

IGc2; Immunoglobulin C-2 Type

smart00409
Location:900 → 977

IG; Immunoglobulin

smart00410
Location:2630 → 2708

IG_like; Immunoglobulin like

cd00054
Location:3772 → 3804

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1840 → 1889

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3312 → 3457

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1035 → 1069

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2711 → 2799

I-set; Immunoglobulin I-set domain

pfam00008
Location:3480 → 3512

EGF; EGF-like domain

pfam00052
Location:1669 → 1794

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1925 → 1955

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3843 → 3972

Laminin_G_2; Laminin G domain

pfam13895
Location:2245 → 2327

Ig_2; Immunoglobulin domain

cl11960
Location:2642 → 2709

Ig; Immunoglobulin domain
NM_001258562.3 → NP_001245491.2 terribly reduced optic lobes, isoform AU [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245491.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NES6, Q8MPN3

Conserved Domains (14) summary

cd05743
Location:1574 → 1649

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:3171 → 3233

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1344 → 1421

IG; Immunoglobulin

smart00410
Location:3074 → 3152

IG_like; Immunoglobulin like

cd00055
Location:2284 → 2333

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3756 → 3901

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1479 → 1513

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:3155 → 3243

I-set; Immunoglobulin I-set domain

pfam00008
Location:3924 → 3956

EGF; EGF-like domain

pfam00052
Location:2113 → 2238

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2369 → 2399

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4287 → 4416

Laminin_G_2; Laminin G domain

pfam13895
Location:2689 → 2771

Ig_2; Immunoglobulin domain

cl11960
Location:3086 → 3153

Ig; Immunoglobulin domain
NM_001258563.3 → NP_001245492.2 terribly reduced optic lobes, isoform AL [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245492.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NGK3

Conserved Domains (15) summary

cd05743
Location:851 → 926

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2448 → 2510

IGc2; Immunoglobulin C-2 Type

smart00409
Location:621 → 698

IG; Immunoglobulin

smart00410
Location:2351 → 2429

IG_like; Immunoglobulin like

cd00054
Location:3493 → 3525

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1561 → 1610

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3033 → 3178

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:756 → 790

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2432 → 2520

I-set; Immunoglobulin I-set domain

pfam00008
Location:3201 → 3233

EGF; EGF-like domain

pfam00052
Location:1390 → 1515

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1646 → 1676

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3564 → 3693

Laminin_G_2; Laminin G domain

pfam13895
Location:1966 → 2048

Ig_2; Immunoglobulin domain

cl11960
Location:2363 → 2430

Ig; Immunoglobulin domain
NM_001414087.1 → NP_001401050.1 terribly reduced optic lobes, isoform BE [Drosophila melanogaster]

Status: REVIEWED
NM_001258567.3 → NP_001245496.2 terribly reduced optic lobes, isoform AI [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245496.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NET2

Conserved Domains (15) summary

cd05743
Location:881 → 956

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2478 → 2540

IGc2; Immunoglobulin C-2 Type

smart00409
Location:2678 → 2754

IG; Immunoglobulin

smart00410
Location:2381 → 2459

IG_like; Immunoglobulin like

cd00054
Location:3662 → 3694

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1591 → 1640

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3202 → 3347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:786 → 820

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2462 → 2550

I-set; Immunoglobulin I-set domain

pfam00008
Location:3370 → 3402

EGF; EGF-like domain

pfam00052
Location:1420 → 1545

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1676 → 1706

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3733 → 3862

Laminin_G_2; Laminin G domain

pfam13895
Location:1996 → 2078

Ig_2; Immunoglobulin domain

cl11960
Location:2393 → 2460

Ig; Immunoglobulin domain
NM_001258569.3 → NP_001245498.2 terribly reduced optic lobes, isoform AP [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245498.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NDM1

Conserved Domains (15) summary

cd05743
Location:929 → 1004

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2526 → 2588

IGc2; Immunoglobulin C-2 Type

smart00409
Location:699 → 776

IG; Immunoglobulin

smart00410
Location:2429 → 2507

IG_like; Immunoglobulin like

cd00054
Location:3571 → 3603

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1639 → 1688

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3111 → 3256

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:834 → 868

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2510 → 2598

I-set; Immunoglobulin I-set domain

pfam00008
Location:3279 → 3311

EGF; EGF-like domain

pfam00052
Location:1468 → 1593

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1724 → 1754

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3642 → 3771

Laminin_G_2; Laminin G domain

pfam13895
Location:2044 → 2126

Ig_2; Immunoglobulin domain

cl11960
Location:2441 → 2508

Ig; Immunoglobulin domain
NM_001258568.3 → NP_001245497.2 terribly reduced optic lobes, isoform AM [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245497.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NGL3, Q8MPN3

Conserved Domains (15) summary

cd05743
Location:1090 → 1165

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2687 → 2749

IGc2; Immunoglobulin C-2 Type

smart00409
Location:860 → 937

IG; Immunoglobulin

smart00410
Location:2590 → 2668

IG_like; Immunoglobulin like

cd00054
Location:3732 → 3764

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1800 → 1849

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3272 → 3417

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:995 → 1029

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2671 → 2759

I-set; Immunoglobulin I-set domain

pfam00008
Location:3440 → 3472

EGF; EGF-like domain

pfam00052
Location:1629 → 1754

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1885 → 1915

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3803 → 3932

Laminin_G_2; Laminin G domain

pfam13895
Location:2205 → 2287

Ig_2; Immunoglobulin domain

cl11960
Location:2602 → 2669

Ig; Immunoglobulin domain
NM_001258571.3 → NP_001245500.2 terribly reduced optic lobes, isoform AR [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245500.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NE61, Q8MPN3

Conserved Domains (15) summary

cd05743
Location:1273 → 1348

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2870 → 2932

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1043 → 1120

IG; Immunoglobulin

smart00410
Location:2773 → 2851

IG_like; Immunoglobulin like

cd00054
Location:3915 → 3947

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1983 → 2032

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3455 → 3600

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1178 → 1212

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2854 → 2942

I-set; Immunoglobulin I-set domain

pfam00008
Location:3623 → 3655

EGF; EGF-like domain

pfam00052
Location:1812 → 1937

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2068 → 2098

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3986 → 4115

Laminin_G_2; Laminin G domain

pfam13895
Location:2388 → 2470

Ig_2; Immunoglobulin domain

cl11960
Location:2785 → 2852

Ig; Immunoglobulin domain
NM_001169177.4 → NP_001162648.3 terribly reduced optic lobes, isoform AH [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162648.3

Status: REVIEWED

UniProtKB/TrEMBL

E1JJC0, Q8MPN3

Conserved Domains (14) summary

cd05743
Location:1534 → 1609

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:3131 → 3193

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1304 → 1381

IG; Immunoglobulin

smart00410
Location:3034 → 3112

IG_like; Immunoglobulin like

cd00055
Location:2244 → 2293

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3716 → 3861

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1439 → 1473

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:3115 → 3203

I-set; Immunoglobulin I-set domain

pfam00008
Location:3884 → 3916

EGF; EGF-like domain

pfam00052
Location:2073 → 2198

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2329 → 2359

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4247 → 4376

Laminin_G_2; Laminin G domain

pfam13895
Location:2649 → 2731

Ig_2; Immunoglobulin domain

cl11960
Location:3046 → 3113

Ig; Immunoglobulin domain
NM_001414086.1 → NP_001401049.1 terribly reduced optic lobes, isoform BD [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPN3
NM_001258566.4 → NP_001245495.2 terribly reduced optic lobes, isoform AK [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245495.2

Status: REVIEWED

UniProtKB/TrEMBL

M9NE56, Q8MPN3

Conserved Domains (14) summary

cd05743
Location:1237 → 1312

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2896 → 2958

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1007 → 1084

IG; Immunoglobulin

smart00410
Location:2799 → 2877

IG_like; Immunoglobulin like

cd00055
Location:1947 → 1996

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3481 → 3626

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1142 → 1176

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2880 → 2968

I-set; Immunoglobulin I-set domain

pfam00008
Location:3649 → 3681

EGF; EGF-like domain

pfam00052
Location:1776 → 1901

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2032 → 2062

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4012 → 4141

Laminin_G_2; Laminin G domain

pfam13895
Location:2414 → 2496

Ig_2; Immunoglobulin domain

cl11960
Location:2811 → 2878

Ig; Immunoglobulin domain
NM_001031863.5 → NP_001027034.2 terribly reduced optic lobes, isoform BB [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVZ0, Q8MPN3

Conserved Domains (13) summary

cd05743
Location:1301 → 1376

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00409
Location:3395 → 3461

IG; Immunoglobulin

smart00410
Location:3098 → 3174

IG_like; Immunoglobulin like

cd00055
Location:2011 → 2060

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3483 → 3628

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1206 → 1240

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00052
Location:1840 → 1976

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2096 → 2126

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4014 → 4143

Laminin_G_2; Laminin G domain

pfam07679
Location:2806 → 2879

I-set; Immunoglobulin I-set domain

pfam13927
Location:2607 → 2675

Ig_3; Immunoglobulin domain

cd00096
Location:2811 → 2818

Ig; Ig strand B [structural motif]

cl11960
Location:2882 → 2970

Ig; Immunoglobulin domain
NM_001031866.4 → NP_001027037.3 terribly reduced optic lobes, isoform AN [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027037.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPN3, Q9W4Y4

Conserved Domains (15) summary

cd05743
Location:1273 → 1348

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2870 → 2932

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1043 → 1120

IG; Immunoglobulin

smart00410
Location:2773 → 2851

IG_like; Immunoglobulin like

cd00054
Location:3915 → 3947

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1983 → 2032

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3455 → 3600

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1178 → 1212

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2854 → 2942

I-set; Immunoglobulin I-set domain

pfam00008
Location:3623 → 3655

EGF; EGF-like domain

pfam00052
Location:1812 → 1937

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2068 → 2098

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3986 → 4115

Laminin_G_2; Laminin G domain

pfam13895
Location:2388 → 2470

Ig_2; Immunoglobulin domain

cl11960
Location:2785 → 2852

Ig; Immunoglobulin domain
NM_001031867.4 → NP_001027038.3 terribly reduced optic lobes, isoform AT [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027038.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPN3, Q9W4Y3

Conserved Domains (14) summary

cd05743
Location:1574 → 1649

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:3171 → 3233

IGc2; Immunoglobulin C-2 Type

smart00409
Location:1344 → 1421

IG; Immunoglobulin

smart00410
Location:3074 → 3152

IG_like; Immunoglobulin like

cd00055
Location:2284 → 2333

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3784 → 3929

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:1479 → 1513

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:3155 → 3243

I-set; Immunoglobulin I-set domain

pfam00008
Location:3952 → 3984

EGF; EGF-like domain

pfam00052
Location:2113 → 2238

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:2369 → 2399

Laminin_EGF; Laminin EGF domain

pfam02210
Location:4315 → 4444

Laminin_G_2; Laminin G domain

pfam13895
Location:2689 → 2771

Ig_2; Immunoglobulin domain

cl11960
Location:3086 → 3153

Ig; Immunoglobulin domain
NM_001382068.1 → NP_001368970.1 terribly reduced optic lobes, isoform BC [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EG25

Conserved Domains (14) summary

cd05743
Location:881 → 956

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00409
Location:2678 → 2754

IG; Immunoglobulin

smart00410
Location:3114 → 3180

IG_like; Immunoglobulin like

cd00054
Location:3370 → 3403

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1591 → 1640

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3202 → 3347

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:786 → 820

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00052
Location:1420 → 1556

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1676 → 1706

Laminin_EGF; Laminin EGF domain

pfam02210
Location:3733 → 3862

Laminin_G_2; Laminin G domain

pfam07679
Location:2386 → 2459

I-set; Immunoglobulin I-set domain

pfam13927
Location:2187 → 2255

Ig_3; Immunoglobulin domain

cd00096
Location:2391 → 2398

Ig; Ig strand B [structural motif]

cl11960
Location:2462 → 2550

Ig; Immunoglobulin domain
NM_001297895.2 → NP_001284824.1 terribly reduced optic lobes, isoform AX [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284824.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JAC7

Conserved Domains (11) summary

cd05743
Location:878 → 953

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2475 → 2537

IGc2; Immunoglobulin C-2 Type

smart00409
Location:2769 → 2830

IG; Immunoglobulin

smart00410
Location:2378 → 2456

IG_like; Immunoglobulin like

cd00055
Location:1588 → 1637

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00112
Location:783 → 817

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2459 → 2547

I-set; Immunoglobulin I-set domain

pfam00052
Location:1417 → 1542

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1673 → 1703

Laminin_EGF; Laminin EGF domain

pfam13895
Location:1993 → 2075

Ig_2; Immunoglobulin domain

cl11960
Location:2390 → 2457

Ig; Immunoglobulin domain
NM_001031865.4 → NP_001027036.3 terribly reduced optic lobes, isoform AG [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027036.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRV7

Conserved Domains (11) summary

cd05743
Location:1130 → 1205

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2727 → 2789

IGc2; Immunoglobulin C-2 Type

smart00409
Location:3021 → 3082

IG; Immunoglobulin

smart00410
Location:2630 → 2708

IG_like; Immunoglobulin like

cd00055
Location:1840 → 1889

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00112
Location:1035 → 1069

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam07679
Location:2711 → 2799

I-set; Immunoglobulin I-set domain

pfam00052
Location:1669 → 1794

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1925 → 1955

Laminin_EGF; Laminin EGF domain

pfam13895
Location:2245 → 2327

Ig_2; Immunoglobulin domain

cl11960
Location:2642 → 2709

Ig; Immunoglobulin domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A023GRW4		A0A023GRW4
A0A6H2EG25		A0A6H2EG25
E1JJC0		E1JJC0
M9NDL5		M9NDL5
M9NDM1		M9NDM1
M9NE56		M9NE56
M9NE61		M9NE61
M9NES6		M9NES6
M9NET2		M9NET2
M9NFR6		M9NFR6
M9NFS1		M9NFS1
M9NGK3		M9NGK3
M9NGL3		M9NGL3
Q7KVZ0		Q7KVZ0
Q8IRV7		Q8IRV7
Q8IRV8		Q8IRV8
Q8IRV9		Q8IRV9
Q8MPN3		Q8MPN3
Q8MRK1		Q8MRK1
Q8MSR5		Q8MSR5
Q95S84		Q95S84
Q9NEF8		Q9NEF8
Q9NEF9		Q9NEF9
Q9NEG0		Q9NEG0
Q9NEG1		Q9NEG1
Q9NFS9		Q9NFS9
Q9W4Y3		Q9W4Y3
Q9W4Y4		Q9W4Y4
X2JAC7		X2JAC7
X2JCE8		X2JCE8
X2JDK9		X2JDK9
X2JE09		X2JE09