U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prosbeta2 Proteasome beta2 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39628, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Prosbeta2provided by FlyBase
    Official Full Name
    Proteasome beta2 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023174
    Locus tag
    Dmel_CG3329
    See related
    AllianceGenome:FB:FBgn0023174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3329; anon-EST:fe1E6; anon-EST:fe1G6; b2; beta 2; Beta 2 subunit; beta-2; Beta-2; beta2; beta2_dm; B[[2]]; CG3329; Dmel\CG3329; DTS-7; DTS57; Dts7; DTS7; l(3)DTS7; prosbeta; Prosbeta; Prosbeta 2; prosbeta2; ProsBeta2; PROSbeta2
    Summary
    Predicted to enable endopeptidase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Prosbeta2 in Genome Data Viewer
    Location:
    71B1-71B1; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14999951..15001319)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14993051..14994419)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene minidiscs Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs Neighboring gene Synaptotagmin beta Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 12-related

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Oxidative stress adaptation with acute, chronic, and repeated stress. Pickering AM, et al. Free Radic Biol Med, 2013 Feb. PMID 23142766, Free PMC Article
    2. Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster. Murali A, et al. Neurobiol Dis, 2014 Jul. PMID 24686303
    3. Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems. Handler AM. Insect Sci, 2016 Apr. PMID 26097098
    4. A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). Katz F, et al. EMBO J, 1988 Nov. PMID 2463162, Free PMC Article
    5. Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis. Velentzas PD, et al. Cell Biol Int, 2011 Jan. PMID 20819072

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These detoxification results represent the first evidence that Prosbeta2 plays a role in the detoxification of DM, which may provide new idea and target for studying the molecular mechanisms of insect resistance
      Title: Identification of proteasome subunit beta type 2 associated with deltamethrin detoxification in Drosophila Kc cells by cDNA microarray analysis and bioassay analyses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proteasome beta2 subunit
    Names
    20s proteasome
    CG3329-PA
    Prosbeta2-PA
    anon-fast-evolving-1E6
    anon-fast-evolving-1G6
    b2 subunit
    beta2
    beta2 proteosome subunit
    beta2 subunit
    proteasome beta2
    NP_524076.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14999951..15001319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079352.4 → NP_524076.2  proteasome beta2 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524076.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17312, Q9VUJ1
      Related
      FBpp0075382
      Conserved Domains (3) summary
      COG0638
      Location:42 → 232
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03763
      Location:42 → 228
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:232 → 264
      Pr_beta_C; Proteasome beta subunits C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17311 O17311
    O17312 O17312
    Q9VUJ1 Q9VUJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous