Pgk Phosphoglycerate kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pgkprovided by FlyBase
Official Full Name: Phosphoglycerate kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0250906
Locus tag: Dmel_CG3127
See related: AllianceGenome:FB:FBgn0250906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 169C9S; anon-sts18; CG3127; Dmel\CG3127; ESTS:169C9S; l(2)23AB3; l(2)23Ac; pgk; PGK; pgk1
Summary: Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Involved in canonical glycolysis; chemical synaptic transmission; and muscle cell cellular homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; larval muscle system; and muscle cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to several human genes including PGK2 (phosphoglycerate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 23A3-23A3; 2-7 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2746880..2753068, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2746880..2753068, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
Title: Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
Title: E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoglycerate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoglycerate kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphoglycerate kinase

Names: CG3127-PA; CG3127-PB; CG3127-PC; CG3127-PD; CG3127-PE; Pgk-PA; Pgk-PB; Pgk-PC; Pgk-PD; Pgk-PE; lethal (2) 23AB3; phosphoglycerokinase

NP_001259956.1

EC 2.7.2.3

NP_001259957.1

EC 2.7.2.3

NP_001259958.1

EC 2.7.2.3

NP_001259959.1

EC 2.7.2.3

NP_476676.1

EC 2.7.2.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2746880..2753068 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273029.1 → NP_001259958.1 phosphoglycerate kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259958.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCG6, Q01604, Q3KN29, Q9VQF6

UniProtKB/TrEMBL

M9PCE0

Conserved Domains (1) summary

cl00198
Location:1 → 414

Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
NM_001273028.1 → NP_001259957.1 phosphoglycerate kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259957.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCG6, Q01604, Q3KN29, Q9VQF6

UniProtKB/TrEMBL

M9PCE0

Conserved Domains (1) summary

cl00198
Location:1 → 414

Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
NM_001273027.1 → NP_001259956.1 phosphoglycerate kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259956.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCG6, Q01604, Q3KN29, Q9VQF6

UniProtKB/TrEMBL

M9PCE0

Conserved Domains (1) summary

cl00198
Location:1 → 414

Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
NM_001273030.1 → NP_001259959.1 phosphoglycerate kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCG6, Q01604, Q3KN29, Q9VQF6

UniProtKB/TrEMBL

M9PCE0

Conserved Domains (1) summary

cl00198
Location:1 → 414

Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
NM_057328.4 → NP_476676.1 phosphoglycerate kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476676.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5XCG6, Q01604, Q3KN29, Q9VQF6

UniProtKB/TrEMBL

M9PCE0

Related

FBpp0077419

Conserved Domains (1) summary

cl00198
Location:1 → 414

Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...