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    CG5214 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5214provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037891
    Locus tag
    Dmel_CG5214
    See related
    AllianceGenome:FB:FBgn0037891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-KGDHC; Dmel\CG5214; GM01350p; Q9VGQ1
    Summary
    Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Involved in cellular respiration. Located in Z disc. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5214 in Genome Data Viewer
    Location:
    86D9-86D9; 3-50 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11244302..11246862)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7070024..7072584)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene SCP-containing protein A Neighboring gene uncharacterized protein Neighboring gene cherub Neighboring gene long non-coding RNA:CR31386

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Dynamics in the Drosophila Ovary Regulates Germ Stem Cell Number, Cell Fate, and Female Fertility. Garcez M, et al. Front Cell Dev Biol, 2020. PMID 33585443, Free PMC Article
    2. A modular toolset of phiC31-based fluorescent protein tagging vectors for Drosophila. Luo J, et al. Fly (Austin), 2019 Mar-Dec. PMID 30885036, Free PMC Article
    3. Genomic imprinting absent in Drosophila melanogaster adult females. Coolon JD, et al. Cell Rep, 2012 Jul 26. PMID 22840398, Free PMC Article
    4. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    5. The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila. González Morales N, et al. J Cell Sci, 2023 Jul 1. PMID 37272588, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue succinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to oxoglutarate dehydrogenase (NAD+) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoadipate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoglutarate dehydrogenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5214-PA
    NP_650064.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11244302..11246862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141807.2 → NP_650064.1  uncharacterized protein Dmel_CG5214 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGQ1
      Related
      FBpp0081834
      Conserved Domains (3) summary
      cd06849
      Location:77 → 149
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:78 → 468
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:255 → 462
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGQ1 Q9VGQ1

    Gene LinkOut

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