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    Cyp4d21 Cytochrome P450 4d21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4d21provided by FlyBase
    Official Full Name
    Cytochrome P450 4d21provided by FlyBase
    Primary source
    FLYBASE:FBgn0031925
    Locus tag
    Dmel_CG6730
    See related
    AllianceGenome:FB:FBgn0031925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4d21; CG6730; cyp4d21; CYP4d21; Dmel\CG6730; sxe1
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in mating. Located in cytoplasm. Is expressed in adult fat body; labellum; organism subdivision; and vibrissal bristle. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4d21 in Genome Data Viewer
    Location:
    28B4-28B4; 2-27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7605600..7607701)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7605600..7607701)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46535 Neighboring gene long non-coding RNA:CR45370 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44799

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing. Schübeler D, et al. Nat Genet, 2002 Nov. PMID 12355067
    2. A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster. Fujii S, et al. Genetics, 2008 Sep. PMID 18716335, Free PMC Article
    3. Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue. Erion R, et al. Elife, 2016 Apr 14. PMID 27077948, Free PMC Article
    4. Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant. Baldwin SR, et al. Sci Rep, 2021 Oct 15. PMID 34654888, Free PMC Article
    5. Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Wirbelauer C, et al. Genes Dev, 2005 Aug 1. PMID 16077006, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sxe1 likely functions as a fatty acid omega-hydroxylase, suggesting that male courtship and mating success is mediated by small compounds generated by this enzyme
      Title: A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 4d21
    Names
    CG6730-PA
    Cyp4d21-PA
    cytochrome P450
    sex-specific enzyme 1
    NP_609129.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7605600..7607701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135285.3 → NP_609129.2  cytochrome P450 4d21 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609129.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLZ7
      UniProtKB/TrEMBL
      Q961G3
      Related
      FBpp0079095
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 482
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961G3 Q961G3
    Q9VLZ7.1 Q9VLZ7

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