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    Scsalpha2 Succinyl-coenzyme A synthetase alpha subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42326, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scsalpha2provided by FlyBase
    Official Full Name
    Succinyl-coenzyme A synthetase alpha subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038708
    Locus tag
    Dmel_CG6255
    See related
    AllianceGenome:FB:FBgn0038708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF55672; anon-WO0140519.197; CG6255; Dmel\CG6255; Scsa2
    Summary
    Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming) and succinate-CoA ligase complex (GDP-forming). Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Scsalpha2 in Genome Data Viewer
    Location:
    92A5-92A5; 3-66 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19461879..19463066, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15287601..15288788, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dystrophin Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity  
    enables succinate-CoA ligase (ADP-forming) activity  
    enables succinate-CoA ligase (GDP-forming) activity  
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle  
    Component Evidence Code Pubs
    is_active_in mitochondrion  
    part_of succinate-CoA ligase complex (ADP-forming)  
    part_of succinate-CoA ligase complex (GDP-forming)  

    General protein information

    Preferred Names
    Succinyl-coenzyme A synthetase alpha subunit 2
    Names
    CG6255-PA
    Scsalpha2-PA
    NP_650809.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19461879..19463066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142552.2 → NP_650809.1  Succinyl-coenzyme A synthetase alpha subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AMM0, Q9VDW7
      Related
      FBpp0083183, FBtr0083769
      Conserved Domains (3) summary
      PTZ00187
      Location:16 → 327
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
      pfam00549
      Location:182 → 306
      Ligase_CoA; CoA-ligase
      pfam02629
      Location:36 → 129
      CoA_binding; CoA binding domain
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