Src42A Src oncogene at 42A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Src42Aprovided by FlyBase
Official Full Name: Src oncogene at 42Aprovided by FlyBase
Primary source: FLYBASE:FBgn0264959
Locus tag: Dmel_CG44128
See related: AllianceGenome:FB:FBgn0264959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14471; CG44128; CG7873; Dm SRC41; Dmel\CG44128; DmHD-29; dSrc; Dsrc41; dSrc42A; Dsrc42A; DSrc42A; dtk-5; dtk5; Dtk5; HD-29; l(2)k10108; pSrc; SK2-4; src; Src; SRC; SRC 42A; Src41; src42; Src42; src42a; src42A; Src42a; SRC42A; Su(D-raf)1; Su(phl)1; Su(Raf)1; Su1; Tk5
Old locus tag: Dmel_CG14471; Dmel_CG7873
Summary: Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including dorsal closure, spreading of leading edge cells; imaginal disc morphogenesis; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult head; epithelial furrow; ganglia; imaginal disc; and tract. Used to study colorectal cancer and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; colorectal cancer (multiple); ductal carcinoma in situ; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to several human genes including FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42A6-42A7; 2-55 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (5981844..6012795)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1869349..1900300)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation.
Title: Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation.
Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila.
Title: Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila.
Suggest a model in which Src42A would sense the inherent anisotropic mechanical tension of the tracheal tube and translate it into a polarised Crumbs accumulation, which may promote a bias towards longitudinal membrane expansion, orienting cell elongation and, as a consequence, longitudinal growth at the tissue level.
Title: Anisotropic Crb accumulation, modulated by Src42A, is coupled to polarised epithelial tube growth in Drosophila.
Src overexpression alone activated the Jun N-terminal Kinase (JNK) signalling pathway to promote actin cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK led to a loss of differentiation and an invasive phenotype.
Title: Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue.
show the same signaling occurs in Drosophila inflammatory cells in response to wound-induced H2O2 with mutants for the Lyn homolog Src42A displaying impaired inflammatory migration to wounds
Title: Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch-Src synergy.
Title: The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis.
Reduction of Src42A function leads to nuclear translocation and activation of FOXO proteins.
Title: Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity.
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
Title: Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.
the Bendless (Ben)/dUev1a ubiquitin E2 complex is an essential regulator of Src42A-induced, JNK-mediated cell migration.
Title: Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila.
Flotillin-2 and constitutively active Src42A are also sufficient, when overexpressed at high levels, to inhibit wound-induced transcription in epidermal cells.
Title: Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, spreading of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response to wounding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sevenless signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Src oncogene at 42A

Names: CG44128-PA; CG44128-PB; CG44128-PC; CG44128-PD; Src42A-PA; Src42A-PB; Src42A-PC; Src42A-PD; src oncogene at 42A; suppressor of pole hole; suppressor of raf-like-oncogene; tyrosine kinase 5

NP_001400983.1

EC 2.7.10.2

NP_001400996.1

EC 2.7.10.2

NP_476849.1

EC 2.7.10.2

NP_610191.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

5981844..6012795

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001414106.1 → NP_001400983.1 Src oncogene at 42A, isoform C [Drosophila melanogaster]

Status: REVIEWED
NM_057501.4 → NP_476849.1 Src oncogene at 42A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18369, Q0E9P0, Q26297, Q94879, Q9V9J3

UniProtKB/TrEMBL

B5X0J6

Related

FBpp0307254

Conserved Domains (3) summary

cd10370
Location:126 → 221

SH2_Src_Src42; Src homology 2 (SH2) domain found in the Src oncogene at 42A (Src42)

cd11845
Location:67 → 118

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:239 → 507

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
NM_001414107.1 → NP_001400996.1 Src oncogene at 42A, isoform D [Drosophila melanogaster]

Status: REVIEWED
NM_136347.2 → NP_610191.2 Src oncogene at 42A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610191.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6I9

Conserved Domains (3) summary

cd10370
Location:1210 → 1301

SH2_Src_Src42; Src homology 2 (SH2) domain found in the Src oncogene at 42A (Src42)

cd05068
Location:1319 → 1587

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

pfam07714
Location:1328 → 1580

Pkinase_Tyr; Protein tyrosine kinase