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    Idgf4 Imaginal disc growth factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idgf4provided by FlyBase
    Official Full Name
    Imaginal disc growth factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0026415
    Locus tag
    Dmel_CG1780
    See related
    AllianceGenome:FB:FBgn0026415
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1780; Dmel\CG1780; DmIDGF4; IDGF; IDGF-4; idgf4; IDGF4; IGDF4
    Summary
    Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and wound healing. Located in extracellular region. Is expressed in several structures, including adult head; epithelium; germline cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Idgf4 in Genome Data Viewer
    Location:
    9A3-9A3; 1-30 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9927973..9930948, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9822006..9824981, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CO2 exposure drives a rapid pH response in live adult Drosophila. Zimmerman SG, et al. PLoS One, 2024. PMID 38625910, Free PMC Article
    2. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393
    3. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells. Kawamura K, et al. Development, 1999 Jan. PMID 9847235
    4. Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response. Sustar AE, et al. Genetics, 2023 Feb 9. PMID 36576887, Free PMC Article
    5. Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions. Zurovcova M, et al. Insects, 2019 Oct 20. PMID 31635152, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c9928201-9928138 mobile_element_type = transposon:INE-1{}5275

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imaginal disc growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    imaginal disc growth factor 4
    Names
    CG1780-PA
    CG1780-PB
    CG1780-PC
    Idgf4-PA
    Idgf4-PB
    Idgf4-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9927973..9930948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298139.1 → NP_001285068.1  imaginal disc growth factor 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V476, O96667, Q9W303
      UniProtKB/TrEMBL
      X2JEB6
      Conserved Domains (2) summary
      cd02873
      Location:26 → 442
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 420
      Glyco_18; Glyco_18 domain

    2. NM_078546.4 → NP_511101.2  imaginal disc growth factor 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511101.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V476, O96667, Q9W303
      UniProtKB/TrEMBL
      X2JEB6
      Related
      FBpp0071328
      Conserved Domains (2) summary
      cd02873
      Location:26 → 442
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 420
      Glyco_18; Glyco_18 domain

    3. NM_167207.3 → NP_727374.1  imaginal disc growth factor 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V476, O96667, Q9W303
      UniProtKB/TrEMBL
      X2JEB6
      Related
      FBpp0071329
      Conserved Domains (2) summary
      cd02873
      Location:26 → 442
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:27 → 420
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W303.1 Q9W303
    X2JEB6 X2JEB6

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