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    CG9062 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9062provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033607
    Locus tag
    Dmel_CG9062
    See related
    AllianceGenome:FB:FBgn0033607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9062
    Summary
    Predicted to enable ubiquitin binding activity. Involved in negative regulation of ubiquitin-dependent protein catabolic process and positive regulation of canonical Wnt signaling pathway. Part of peptidase complex. Is expressed in adult head and organism. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9062 in Genome Data Viewer
    Location:
    47E5-47E6; 2-64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11280484..11283971, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7167989..7171476, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 47Eg Neighboring gene uncharacterized protein Neighboring gene von Hippel-Lindau Neighboring gene uncharacterized protein Neighboring gene F-box and leucine-rich repeat protein 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Spencer ZT, et al. Nat Commun, 2023 Oct 5. PMID 37798281, Free PMC Article
    2. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
    3. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Sen A, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23757500, Free PMC Article
    4. Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells in Drosophila. Earl JB, et al. G3 (Bethesda), 2020 Nov 5. PMID 32972998, Free PMC Article
    5. Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A. Moshkin YM, et al. PLoS Genet, 2013. PMID 24086141, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deubiquitinase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9062-PB
    CG9062-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11280484..11283971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273957.1 → NP_001260886.1  uncharacterized protein Dmel_CG9062, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET0
      Conserved Domains (4) summary
      COG2319
      Location:24 → 332
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:27 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam11816
      Location:492 → 658
      DUF3337; Domain of unknown function (DUF3337)
      sd00039
      Location:77 → 113
      7WD40; WD40 repeat [structural motif]

    2. NM_165814.3 → NP_725018.1  uncharacterized protein Dmel_CG9062, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1LZ08, Q8IGK7
      Related
      FBpp0087277
      Conserved Domains (4) summary
      COG2319
      Location:24 → 332
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:27 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam11816
      Location:492 → 658
      DUF3337; Domain of unknown function (DUF3337)
      sd00039
      Location:77 → 113
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KET0 A0A0B4KET0
    Q1LZ08.1 Q1LZ08

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